[环孢素对大鼠同种异体心脏移植存活时间的影响]。

Zeitschrift fur experimentelle Chirurgie, Transplantation, und kunstliche Organe : Organ der Sektion Experimentelle Chirurgie der Gesellschaft fur Chirurgie der DDR Pub Date : 1989-01-01

H Oesterwitz, S Gruner, W Schneider

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引用次数: 0

摘要

本研究的目的是研究心脏供体在第1天给予25或50 mg kg BW的环孢素(CsA)预处理对主要组织相容性复合体(MHC)不同的供体-受体组合大鼠同种异体心脏移植存活时间的影响。没有进一步的免疫抑制。与未处理的对照组相比，经csa预处理的同种异体心脏移植受者的生存期明显延长，10个移植物中有3个(25 mg kg)和9个移植物中有4个(50 mg kg)永久存活。这些初步的实验结果是新的，但需要进一步的研究来提高这种预处理方案的效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

[The effect of donor conditioning with cyclosporin on the survival time of allogenic heart transplants in the rat].

The aim of the study was to investigate the influence of a pretreatment of the heart donor with cyclosporin (CsA) at 25 or 50 mg kg BW on day -1 on survival time of rat heart allografts in a donor-recipient combination that was different at their major histocompatibility complex (MHC). No further immunosuppression was used. The survival of CsA-pretreated heart transplants was significantly prolonged in allogeneic recipients compared with untreated controls and 3 out of 10 grafts (25 mg kg) and 4 out of 9 grafts (50 mg kg) survived permanently. These preliminary experimental findings are new, but further investigations are necessary to increase the efficacy of this pretreatment protocol.

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来源期刊

Zeitschrift fur experimentelle Chirurgie, Transplantation, und kunstliche Organe : Organ der Sektion Experimentelle Chirurgie der Gesellschaft fur Chirurgie der DDR

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