静脉注射碘曲兰在健康志愿者体内的药代动力学。

Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband Pub Date : 1989-01-01

P Scholz, H J Weinmann, W Mützel, T Staks

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引用次数: 0

摘要

人静脉注射后碘曲兰分布于血管外空间，半衰期约为11分钟，消除半衰期约为108分钟。静脉注射后5天内尿中发现99.2 +/- 1.8%，粪便中发现0.5 +/- 0.1%。在人体中没有发生代谢，碘曲兰的药代动力学行为与已知的非离子造影剂(如碘己醇、碘丙胺)相当(7,9,13)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Pharmacokinetics of iotrolan after intravenous injection into healthy volunteers.

In man Iotrolan is distributed in the extravascular space after intravenous injection with a half-life of about 11 minutes, the elimination half-life being about 108 minutes. After intravenous injection 99.2 +/- 1.8% of the dose was found in the urine and 0.5 +/- 0.1% in the feces within 5 days. No metabolization occurred in man and the pharmacokinetic behavior of iotrolan is comparable to that of known nonionic contrast media (e.g., iohexol, iopromide) (7, 9, 13).

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Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband

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