W Tuganowski, I Korczyńska, K Wasik, B Wójcik, M Bukowski
{"title":"福斯可林对兔窦结条纵向内阻的影响。","authors":"W Tuganowski, I Korczyńska, K Wasik, B Wójcik, M Bukowski","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The effect of several concentrations of 7-0-hemisuccinyl, 7-deacetyl forskolin on ri was studied by means of microelectrode and single sucrose gap techniques. Twenty mumol.l-1 of forskolin added to the sucrose gap lowered ri by 15% below the control value. The drug applied at 50 mumol.l-1 initially decreased ri by 31%, and then it increased the resistance by 43% above the control value. The possible mechanisms underlying these effects are discussed in terms of cAMP and Ca action on the cell coupling.</p>","PeriodicalId":7158,"journal":{"name":"Acta physiologica Polonica","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1989-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of forskolin on the longitudinal internal resistance (ri) in rabbit sinus node strips.\",\"authors\":\"W Tuganowski, I Korczyńska, K Wasik, B Wójcik, M Bukowski\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The effect of several concentrations of 7-0-hemisuccinyl, 7-deacetyl forskolin on ri was studied by means of microelectrode and single sucrose gap techniques. Twenty mumol.l-1 of forskolin added to the sucrose gap lowered ri by 15% below the control value. The drug applied at 50 mumol.l-1 initially decreased ri by 31%, and then it increased the resistance by 43% above the control value. The possible mechanisms underlying these effects are discussed in terms of cAMP and Ca action on the cell coupling.</p>\",\"PeriodicalId\":7158,\"journal\":{\"name\":\"Acta physiologica Polonica\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1989-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta physiologica Polonica\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta physiologica Polonica","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effects of forskolin on the longitudinal internal resistance (ri) in rabbit sinus node strips.
The effect of several concentrations of 7-0-hemisuccinyl, 7-deacetyl forskolin on ri was studied by means of microelectrode and single sucrose gap techniques. Twenty mumol.l-1 of forskolin added to the sucrose gap lowered ri by 15% below the control value. The drug applied at 50 mumol.l-1 initially decreased ri by 31%, and then it increased the resistance by 43% above the control value. The possible mechanisms underlying these effects are discussed in terms of cAMP and Ca action on the cell coupling.
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