{"title":"昂丹西琼注射液的研制。","authors":"R E Leak, J D Woodford","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Ondansetron injection is an aqueous solution containing ondansetron base as the hydrochloride dihydrate. The pH of the injection was selected to achieve good physical and chemical stability. The shelf life is 3 years when stored below 30 degrees C, protected from light. Ondansetron injection may be diluted for administration by slow intravenous injection or infusion and is compatible with several intravenous infusion fluids. In addition, specific concentrations of cisplatin, 5-fluorouracil, carboplatin, etoposide, ceftazidime, cyclophosphamide and doxorubicin are compatible when administered via a giving set delivering ondansetron by infusion.</p>","PeriodicalId":11941,"journal":{"name":"European journal of cancer & clinical oncology","volume":"25 Suppl 1 ","pages":"S67-9"},"PeriodicalIF":0.0000,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Pharmaceutical development of ondansetron injection.\",\"authors\":\"R E Leak, J D Woodford\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Ondansetron injection is an aqueous solution containing ondansetron base as the hydrochloride dihydrate. The pH of the injection was selected to achieve good physical and chemical stability. The shelf life is 3 years when stored below 30 degrees C, protected from light. Ondansetron injection may be diluted for administration by slow intravenous injection or infusion and is compatible with several intravenous infusion fluids. In addition, specific concentrations of cisplatin, 5-fluorouracil, carboplatin, etoposide, ceftazidime, cyclophosphamide and doxorubicin are compatible when administered via a giving set delivering ondansetron by infusion.</p>\",\"PeriodicalId\":11941,\"journal\":{\"name\":\"European journal of cancer & clinical oncology\",\"volume\":\"25 Suppl 1 \",\"pages\":\"S67-9\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1989-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European journal of cancer & clinical oncology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European journal of cancer & clinical oncology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Pharmaceutical development of ondansetron injection.
Ondansetron injection is an aqueous solution containing ondansetron base as the hydrochloride dihydrate. The pH of the injection was selected to achieve good physical and chemical stability. The shelf life is 3 years when stored below 30 degrees C, protected from light. Ondansetron injection may be diluted for administration by slow intravenous injection or infusion and is compatible with several intravenous infusion fluids. In addition, specific concentrations of cisplatin, 5-fluorouracil, carboplatin, etoposide, ceftazidime, cyclophosphamide and doxorubicin are compatible when administered via a giving set delivering ondansetron by infusion.
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