人体衰老过程中红细胞的氧转运功能与能量代谢

Zeitschrift fur Alternsforschung Pub Date : 1989-03-01

O V Korkusko, L A Ivanov, A V Pisaruk

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引用次数: 0

摘要

研究了血红蛋白对氧亲和力的年龄相关变化以及决定它的红细胞内因子(pH、pCO2、糖酵解速率、有机磷含量)。结果表明，尽管红细胞的能量代谢受到抑制，红细胞中有机磷含量降低，但红细胞内培养基pH降低导致血红蛋白对氧亲和力的老化(玻尔效应)。

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[The oxygen transport function and energy metabolism of erythrocytes in human aging].

Age-related changes of hemoglobin affinity to oxygen and intraerythrocyte factors which determine it (pH, pCO2, rate of glycolysis, content of organic phosphates) were studied. The results obtained showed the decrease in aging of the affinity of hemoglobin to oxygen resultant from the decrease of pH of intraerythrocyte medium (Bohr effect), despite the inhibited energy metabolism and decreased content of organic phosphates in erythrocytes.

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Zeitschrift fur Alternsforschung

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