单双Preserflo微分流植入青光眼患者:一项回顾性队列研究。

IF 2 4区 医学 Q2 OPHTHALMOLOGY
Ophthalmic Research Pub Date : 2023-01-01 Epub Date: 2023-11-16 DOI:10.1159/000535276
Thomas Dervos, Konstantin Gugleta, Hendrik P N Scholl, Zisis Gatzioufas, Tim J Enz
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引用次数: 0

摘要

本研究的目的是描述和评价双Preserflo MicroShunt植入术作为一种改良的微创青光眼手术技术,并回顾性比较单次或双次植入术青光眼患者的结果。材料与方法对57例连续行Preserflo植入术的青光眼患者进行回顾性分析。检查了患者的人口统计学、青光眼类型、眼压(IOP)、药物、并发症和再干预等医疗记录。分为单次植入组(n=29)和双次植入组(n=28)进行比较。在两阶段双种植的病例(n=17)中,比较第一次和第二次种植的过程。结果双眼植入术组术前平均IOP明显高于单眼植入术组(29.4±10.0mmHg;21.7±8.2毫米汞柱;P = 0.003)。术后不同时间点(第1天、第1周、第3个月、第6个月;所有P
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Single versus Double PreserFlo MicroShunt Implantation in Glaucoma Patients: A Retrospective Cohort Study.

Introduction: The aim of this study was to describe and evaluate double PreserFlo MicroShunt implantation as a modified micro-invasive glaucoma surgery technique and to retrospectively compare the outcomes in a cohort of glaucoma patients with single or double implantation.

Materials and methods: A retrospective data analysis of 57 glaucoma patients who consecutively underwent PreserFlo implantation was performed. Medical records were examined for patients' demographics, glaucoma type, intraocular pressure (IOP), medication, complications, and re-interventions. Two groups with single (n = 29) or double (n = 28) implantation were formed, and the outcomes were compared. In cases of two-stage double implantation (n = 17), the courses of the initial and the second implantations were compared.

Results: Mean preoperative IOP was significantly higher in the double compared to the single implantation group (29.4 ± 10.0 mm Hg; 21.7 ± 8.2 mm Hg; p = 0.003). Postoperatively, IOP was significantly lower in the double implantation group at various time-points (day 1, week 1, months 3 and 6; all p < 0.021). In the subgroup with two-stage procedures, mean preoperative IOP was 24.5 ± 8.5 mm Hg and 29.8 ± 10.1 mm Hg, respectively (p = 0.128). While immediately postoperatively, mean IOP lowering was clinically significant and similar following both procedures, the longer sustainable effect was observed after the second procedure (month 12: 25.5 ± 7.5 mm Hg; 12.4 ± 4.8 mm Hg; p = 0.001). No serious complications were observed.

Discussion/conclusion: Double PreserFlo implantation appears safe and efficient for lowering IOP in glaucoma patients. Our preliminary findings suggest that double is superior to single implantation in terms of IOP lowering and the need for additional topical medication. Patients with insufficient IOP lowering following single implantation may benefit from a second implantation. Further research is warranted to evaluate double implantation as a first-line, one-stage procedure.

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来源期刊
Ophthalmic Research
Ophthalmic Research 医学-眼科学
CiteScore
3.80
自引率
4.80%
发文量
75
审稿时长
6-12 weeks
期刊介绍: ''Ophthalmic Research'' features original papers and reviews reporting on translational and clinical studies. Authors from throughout the world cover research topics on every field in connection with physical, physiologic, pharmacological, biochemical and molecular biological aspects of ophthalmology. This journal also aims to provide a record of international clinical research for both researchers and clinicians in ophthalmology. Finally, the transfer of information from fundamental research to clinical research and clinical practice is particularly welcome.
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