单克隆战争:抗体库和扩大应用的靶点

Immuno Pub Date : 2023-09-20 DOI:10.3390/immuno3030021

Eric H. Rosenn, Mickael Benhaim, Allison Siegel, David A. Stein, Joseph S. Leonard, Erik Katcher, Dania Halperin, Zachary Mostel

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引用次数: 0

摘要

测序和筛选技术的进步使单克隆抗体更容易获得，成本效益更高，更精确。这些药物有效地靶向病原体和癌细胞，甚至通过专注于特定的中间体来调节代谢途径。单克隆抗体在减轻职业相关癌症、神经退行性疾病和多药耐药生物的上升中发挥关键作用。在这里，我们回顾了这一重要药物类别的起源、机制和应用，并探讨了未来的研究途径。

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Monoclonal War: The Antibody Arsenal and Targets for Expanded Application

Advancements in sequencing and screening technology have made monoclonal antibodies more accessible, cost-effective, and precise. These drugs effectively target pathogens and cancer cells and even regulate metabolic pathways by focusing on specific intermediates. Monoclonal antibodies play a key role in mitigating a rise in occupation-related cancers, neurodegenerative disorders, and multidrug-resistant organisms. Here, we review the origins, mechanisms, and applications of this important drug class and explore future avenues for research.

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Immuno

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