打折期,lt; gt; Magnusiomyces菌capitatus&肝移植;打折期/ gt;免疫功能正常的肺出血和系统性红斑狼疮患者

Waleed Amasaib Ahmed, Angham Ahmed Almakki, Abeer Ahmed Bashinim, Abdelgaffar A. Mohamed, Amna Al Kalkami, Mohannad AbuRageila
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引用次数: 0

摘要

在过去的二十年中,由于免疫功能低下的宿主和老年患者的增加,侵袭性真菌感染显著增长。当宿主的防御被破坏时,这种感染与严重的发病率和死亡率有关。本文报告了一例罕见的真菌感染病例,患者为来自沙特阿拉伯的61岁男性免疫功能正常,患有肺出血和系统性红斑狼疮。支气管肺泡灌洗作为诊断工具,以确定真菌报告的情况下。在菌落的宏观和微观形态特征上,鉴定病原真菌属Magnusiomyces capitatus。基于临床证据,两性霉素脂质体制剂被推荐用于抗真菌感染的初始治疗。此外,两性霉素B脂质体诱导的真菌学根除高达70%的患者确诊的Magnusiomyces capitatus感染。除了解决疑似系统性红斑狼疮外,患者的健康状况有所改善,无肺出血和咯血的证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
<i>Magnusiomyces capitatus</i> in Immune-Competent Patients with Pulmonary Haemorrhage and Systemic Lupus Erythematosus
Invasive fungal infections have grown significantly over the last two decades, owing to an increase in immunocompromised hosts and geriatric patients. When the host’s defenses are compromised, such infections are associated with severe morbidity and mortality. Here, a rare case of fungal infection in a 61-year-old immunocompetent male patient from Saudi Arabia was reported, who suffered from pulmonary hemorrhage and Systemic Lupus Erythematous. Bronchoalveolar Lavage was used as a diagnostic tool to identify the fungus reported in the case. The pathogenic fungal specie identified as Magnusiomyces capitatus, in macroscopic and microscopic morphological characteristics of the colonies. Based on clinical evidence, liposomal amphotericin formulation was recommended for initial therapy against fungal infection. Also, liposomal amphotericin B induced mycological eradication up to 70 percent in patients with proven Magnusiomyces capitatus infection. In addition to addressing suspected Systemic lupus erythematosus, the patient’s health has improved with no evidence of pulmonary bleeding and hemoptysis.
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