探索富含乙醇酸、芦荟和维生素e的日常洗面奶对痤疮管理的临床效果和使用模式:事后分析

Pradeep Kumari, Deepa K. Bhatt, K. Manoharan, Praveen Agarwal, B. Leelavathy, Anurag Arya, Rathish Nair, Krishnaprasad Korukonda
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摘要

背景:洁面乳被推荐作为痤疮治疗的辅助产品,以抵消痤疮相关的表现,如痤疮斑点和炎症后色素沉着(PIH)。本补充研究旨在评估乙醇酸、芦荟和维生素e洁面乳的临床影响和耐受性,在现实世界中,痤疮患者使用克林霉素、维甲酸、阿达帕烯和过氧化苯甲酰治疗痤疮。方法:我们在193个中心进行了回顾性研究,重点关注每天使用两次洗面奶的油性和混合性皮肤类型的痤疮患者。对619例痤疮患者(D年龄:28.94±7.92岁)进行为期4周的分析,采用主观评价问卷,研究炎症后色素沉着、痤疮斑减少、皮肤光泽度和容光度的改善情况。结果:定期使用标准护理洁面乳后,痤疮(43.58%)、痘斑(44.85%)、PIH(46.06%)明显减少,差异有统计学意义(p<0.01)。油性和混合性皮肤类型的患者分别有337名(54.44%)和264名(42.65%)认为痤疮斑、PIH、光照度和容光度的改善从好到好。没有患者出现严重不良事件(ae)或清洁剂相关不良事件。结论:该洗面奶对联合抗菌和抗炎药物治疗的痤疮患者具有良好的疗效和耐受性。在长达4周的治疗期间,洗面奶增强了皮肤的光泽,也证明了它作为日常护肤方案的有益成分的价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exploring clinical effects and usage patterns of a daily face cleanser enriched with glycolic acid, aloe vera, and vitamin-E for acne management: a post-hoc analysis
Background: Face cleansers are recommended as adjuncts to acne therapy to counteract the acne related manifestation like acne spots and post inflammatory hyperpigmentation (PIH). This complementary study was designed to assess the clinical impact and tolerability of glycolic acid, aloe vera and vitamin-E based face cleanser for daily use in acne patients prescribed with clindamycin, tretinoin, adapalene and benzoyl peroxide for management of acne in real-world scenario. Methods: We conducted a retrospective review at 193 centres, focusing on individuals having acne with oily and mix skin types who used face cleanser twice a day. Total 619 cases (D age: 28.94±7.92 years) of acne were further analysed over a 4-week study period to study improvement in post-inflammatory hyperpigmentation, acne spot reduction and enhance skin radiance and glow using subjective assessment questionnaires. Results: The face cleanser, when used regularly with standard of care, significantly reduced acne (43.58%), acne spots (44.85%), and PIH (46.06%) with statistical significance (p<0.01). Patients with oily and mix skin type, 337 (54.44%) and 264 (42.65%) rated improvement on acne spots, PIH, radiance, and glow to be good to excellent, respectively. No patients experienced serious adverse events (AEs) or cleanser-related adverse event. Conclusions: The facial cleanser demonstrated effectiveness and tolerance in treating acne patients who were prescribed with anti-bacterial and anti-inflammatory agents. In 4-week long treatment period, the facial cleanser enhanced skin radiance and also demonstrated its worth as a beneficial inclusion in everyday skincare regimens.
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