藏红花乙醇提取物对庆大霉素所致大鼠肾毒性的保护作用

IF 0.5 Q4 EDUCATION, SCIENTIFIC DISCIPLINES

Pharmacy Education Pub Date : 2023-10-10 DOI:10.46542/pe.2023.234.3236

Ika Puspita Dewi, Fifteen Aprila Fajrin, Nadia Kholidatul Yumna, Hesti Nur Rahmawati, Fransiska Maria Christanty, Diana Holidah

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引用次数: 0

摘要

背景:肾脏是包括药物在内的有毒物质的主要靶器官之一。庆大霉素引起的肾毒性被认为是由氧化应激的形成引起的，可以通过抗氧化剂来预防。藏红花具有较强的抗氧化活性。目的:研究藏红花的肾保护作用。方法:以Wistar大鼠为实验对象，分为正常组、阴性组和藏红花乙醇提取物(剂量分别为250、500、750 mg/kg BW) 5组。庆大霉素诱导肾毒性8 d。第9天测定肾功能参数(血、尿素、氮、肌酐、尿酸)和丙二醛水平，并进行肾脏组织学分析。结果:与阴性对照组相比，提取液的肾功能指标和丙二醛水平明显降低。结论:藏红花是一种潜在的肾保护剂。

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Protective effects of Piper crocatum ethanol extract on Gentamicin-induced nephrotoxicity in rats

Background: The kidney is one of the main target organs of toxic substances, including drugs. Gentamicin-induced nephrotoxicity is thought to be caused by the formation of oxidative stress and can be prevented by antioxidants. Piper crocatum has potent antioxidant activity. Objective: This study aims to determine the nephroprotective activity of Piper crocatum. Method: The study used Wistar rats in five groups (normal, negative, and ethanol extract of Piper crocatum with doses of 250, 500, and 750 mg/kg BW). The nephrotoxicity was induced by gentamicin for eight days. On the ninth day, the kidney function parameters (blood, urea, nitrogen, creatinine and uric acid) and malondialdehyde levels were measured, and kidney histology analysis was performed. Results: The results demonstrated that the extracts show lower kidney function parameters and malondialdehyde levels than the negative control. Conclusion: Piper crocatum is a potential nephroprotective agent.

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来源期刊

Pharmacy Education EDUCATION, SCIENTIFIC DISCIPLINES-

CiteScore

0.80

自引率

20.00%

发文量

174

期刊介绍： Pharmacy Education journal provides a research, development and evaluation forum for communication between academic teachers, researchers and practitioners in professional and pharmacy education, with an emphasis on new and established teaching and learning methods, new curriculum and syllabus directions, educational outcomes, guidance on structuring courses and assessing achievement, and workforce development. It is a peer-reviewed online open access platform for the dissemination of new ideas in professional pharmacy education and workforce development. Pharmacy Education supports Open Access (OA): free, unrestricted online access to research outputs. Readers are able to access the Journal and individual published articles for free - there are no subscription fees or ''pay per view'' charges. Authors wishing to publish their work in Pharmacy Education do so without incurring any financial costs.