治疗再生障碍性贫血的中药

IF 2.9 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Jing Guan, YiHui Zhao, Ting Wang, Rong Fu
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引用次数: 0

摘要

再生障碍性贫血(AA)是一种由T细胞功能亢进引起的骨髓衰竭疾病。尽管免疫抑制疗法(IST)加依曲巴格(Eltrombopag)提高了总缓解率,但30%的患者没有缓解或复发。因此,我们试图寻找其他方法来改善AA患者的预后。中药具有成本低、疗效合理、副作用少等优点。越来越多的临床研究证实,中药对AA患者有有益的治疗作用。本文就中药及其有效成分治疗AA的潜在机制作一综述。这些包括改善骨髓微环境,调节免疫,影响造血干细胞的命运。这为进一步中西医结合治疗AA和制定新的治疗策略提供了有益的信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Traditional Chinese medicine for treating aplastic anemia
Aplastic anemia (AA) is a bone marrow failure disease caused by T cell hyperfunction. Although the overall response rate has been improved by immunosuppressive therapy (IST) plus Eltrombopag, 30% of patients have either no response or relapse. We therefore attempted to find other ways to improve the outcomes of AA patients. Traditional Chinese medicine has the advantages of low cost, reasonable effects, and few side effects. More and more clinical studies have confirmed that traditional Chinese medicine has a beneficial role in treating AA patients. This article reviews the potential mechanism of traditional Chinese medicine or its active ingredients in the treatment of AA. These include improving the bone marrow microenvironment, regulating immunity, and affecting the fate of hematopoietic stem cells. This provides useful information for further treatment of AA with integration of traditional Chinese and Western medicine and the development of new treatment strategies.
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来源期刊
CiteScore
6.90
自引率
0.00%
发文量
29
审稿时长
6-12 weeks
期刊介绍: The Journal of Pharmacy and Pharmaceutical Sciences (JPPS) is the official journal of the Canadian Society for Pharmaceutical Sciences. JPPS is a broad-spectrum, peer-reviewed, international pharmaceutical journal circulated electronically via the World Wide Web. Subscription to JPPS is free of charge. Articles will appear individually as soon as they are accepted and are ready for circulation.
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