{"title":"非整倍体囊胚发育中精子形态与染色质完整性的关系:诊断为畸形精子症的精子受精胚胎","authors":"Jesús Estuardo Luján-Irastorza","doi":"10.58779/issn.2954-467x.tjor2023.v2.n2.28","DOIUrl":null,"url":null,"abstract":"Objective: Evaluate whether the presence of aneuploid blastocysts is associated with sperm morphology and fragmentation.Methods: Retrospective, observational and cross-sectional study, which included 352 embryos in blastocyst stage, obtained by intracytoplasmic sperm injection (ICSI) from 131 cycles of patients with implantation failure and who decided to perform preimplantation genetic study of aneuploidy (PGT-A) to the embryos that were transferred to the uterus, in order to improve the implantation rate.Results: Of the embryos obtained from donated oocytes, only those fertilized with semen diagnosed with teratozoospermia presented aneuploidy (26.6%). The rate of aneuploid embryos was similar when own oocytes were fertilized with semen diagnosed with normozoospermia or teratozoospermia (38.4 vs 37.07%). Finally, no relationship was observed between chromatin damage and sperm morphology.
 
 
","PeriodicalId":494727,"journal":{"name":"The Journal of Reproduction","volume":"3 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Relationship of morphology and chromatin integrity of sperm in aneuploid blastocyst development: embryos fertilized with sperm diagnosed with teratozoospermia\",\"authors\":\"Jesús Estuardo Luján-Irastorza\",\"doi\":\"10.58779/issn.2954-467x.tjor2023.v2.n2.28\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective: Evaluate whether the presence of aneuploid blastocysts is associated with sperm morphology and fragmentation.Methods: Retrospective, observational and cross-sectional study, which included 352 embryos in blastocyst stage, obtained by intracytoplasmic sperm injection (ICSI) from 131 cycles of patients with implantation failure and who decided to perform preimplantation genetic study of aneuploidy (PGT-A) to the embryos that were transferred to the uterus, in order to improve the implantation rate.Results: Of the embryos obtained from donated oocytes, only those fertilized with semen diagnosed with teratozoospermia presented aneuploidy (26.6%). The rate of aneuploid embryos was similar when own oocytes were fertilized with semen diagnosed with normozoospermia or teratozoospermia (38.4 vs 37.07%). Finally, no relationship was observed between chromatin damage and sperm morphology.
 
 
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引用次数: 0
摘要
目的:探讨非整倍体囊胚的存在是否与精子形态和破碎有关。方法:回顾性、观察性、横断面研究，选取131周期着床失败且决定对移植至子宫的胚胎进行非整倍体(PGT-A)着床前遗传学研究的患者，通过卵胞浆内单精子注射(ICSI)获得352个囊胚期胚胎，以提高着床率。结果:在捐赠卵母细胞获得的胚胎中，只有与诊断为畸形精子症的精液受精的胚胎出现非整倍体(26.6%)。当自身卵母细胞与诊断为正常精子症或畸形精子症的精液受精时，非整倍体胚胎的发生率相似(38.4% vs 37.07%)。最后，没有观察到染色质损伤与精子形态之间的关系。
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Relationship of morphology and chromatin integrity of sperm in aneuploid blastocyst development: embryos fertilized with sperm diagnosed with teratozoospermia
Objective: Evaluate whether the presence of aneuploid blastocysts is associated with sperm morphology and fragmentation.Methods: Retrospective, observational and cross-sectional study, which included 352 embryos in blastocyst stage, obtained by intracytoplasmic sperm injection (ICSI) from 131 cycles of patients with implantation failure and who decided to perform preimplantation genetic study of aneuploidy (PGT-A) to the embryos that were transferred to the uterus, in order to improve the implantation rate.Results: Of the embryos obtained from donated oocytes, only those fertilized with semen diagnosed with teratozoospermia presented aneuploidy (26.6%). The rate of aneuploid embryos was similar when own oocytes were fertilized with semen diagnosed with normozoospermia or teratozoospermia (38.4 vs 37.07%). Finally, no relationship was observed between chromatin damage and sperm morphology.
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