术前给药地塞米松和β2激动剂对气道异物患儿术中呼吸并发症的影响

IF 0.4 4区 医学 Q4 PEDIATRICS
Ufuk Ates, Ergun Ergun, Kutay Bahadir, Ozlem Selvi Can, Anar Gurbanov, Coskun Ozbicer, Murat Cakmak, Meltem Bingol-Kologlu, Gulnur Gollu
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引用次数: 0

摘要

背景:对麻醉师和外科医生来说,儿童手术中最具挑战性的手术之一是异物吸出。支气管痉挛和去饱和可导致心动过缓甚至死亡。目的:本研究旨在评价硬支气管镜下异物吸入患儿术前给予地塞米松和β2激动剂(沙丁胺醇)对不良并发症的影响。方法:根据患儿的临床情况,采用随机数字表法将患儿分为两组。β2激动剂(沙丁胺醇)(2.5 mg <20kg, 5mg >1组患者术前30分钟给予地塞米松0.5 mg/kg。组2在麻醉诱导时给予相同的药物。评估支气管痉挛、去饱和和心动过缓的发生情况。结果:每组患儿27例。两组患者出现症状的时间与手术时间无统计学差异(P >0.05)。两组在临床方面相似。临床上,1组痉挛时间和去饱和时间较短,患者恢复较快,但两组支气管痉挛次数、去饱和时间和心动过缓时间相似。结论:结果在统计学上似乎是相似的。由于术前给予β2激动剂(沙丁胺醇)和地塞米松的患者痉挛和去饱和期更短,恢复更快,因此我们认为,在未来的研究中,更大的数据集可能会导致更显著的结果和更好的结论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Preoperative Dexamethasone and β2 Agonist Administration to Children with Airway Foreign Bodies: Effects on Intraoperative Respiratory Complications
Background: One of the most challenging operations in children for anesthesiologists and surgeons is foreign body aspiration. Bronchospasm and desaturation may lead to bradycardia and even death. Objectives: The study aimed to evaluate the effect of preoperative dexamethasone and β2 agonist (salbutamol) administration on children who had foreign body aspiration during the rigid bronchoscopy on these undesired complications. Methods: Children were divided into two groups via random numbers table, independent of their clinical conditions. β2 agonist (salbutamol) (2.5 mg < 20 kg, 5 mg > 20 kg) and dexamethasone (0.5 mg/kg) were administrated to group 1, 30 minutes before the operation. The same agents were administrated to group 2 during anesthesia induction. The occurrence of bronchospasm, desaturation, and bradycardia was evaluated. Results: There were 27 children in each group. There was no statistically significant difference between the two groups’ time periods between the onset of the symptoms and procedure (P > 0.05). The two groups were similar in clinical aspects. Clinically, periods of spasm and desaturation were shorter, and patients recovered faster in group 1, but the bronchospasm numbers, desaturation, and bradycardia periods were similar in both groups. Conclusions: The results seem statistically similar. Since the periods of spasm and desaturation were shorter, and patients recovered faster in patients with preoperative administration of β2 agonists (salbutamol) and dexamethasone, we may suggest that a larger data set in future studies may lead to more significant results and a better conclusion.
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来源期刊
CiteScore
0.90
自引率
20.00%
发文量
75
审稿时长
6-12 weeks
期刊介绍: Iranian Journal of Pediatrics (Iran J Pediatr) is a peer-reviewed medical publication. The purpose of Iran J Pediatr is to increase knowledge, stimulate research in all fields of Pediatrics, and promote better management of pediatric patients. To achieve the goals, the journal publishes basic, biomedical, and clinical investigations on prevalent diseases relevant to pediatrics. The acceptance criteria for all papers are the quality and originality of the research and their significance to our readership. Except where otherwise stated, manuscripts are peer-reviewed by minimum three anonymous reviewers. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence as the material cannot be returned. Final acceptance or rejection rests with the Editors.
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