外侧缰-腹侧被盖区微回路对疼痛相关认知功能障碍的影响

IF 3.2 Q2 CLINICAL NEUROLOGY
Ana Raquel Pereira, Mobina Alemi, Mariana Cerqueira-Nunes, Clara Monteiro, Vasco Galhardo, Helder Cardoso-Cruz
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引用次数: 0

摘要

慢性疼痛是一种影响工作和其他活动能力的健康问题,通常会随着时间的推移而恶化。了解复杂的疼痛与大脑回路的相互作用可以帮助预测哪些患者有中枢功能障碍的风险。临床前和临床研究越来越多的证据表明,外侧链(LHb)的异常活动与以过度消极注意力为特征的抑郁症状有关,导致高度认知功能障碍。LHb的主要输出区域是腹侧被盖区(VTA),通过双向连接。最近,人们对LHb和VTA之间复杂的相互作用越来越感兴趣,特别是它们在行为调节中的关键作用以及它们在慢性疼痛对认知功能的病理影响中的潜在参与。在这篇综述中,我们简要讨论了LHb-VTA微电路的结构和功能作用及其对认知和情绪障碍的影响,以支持未来关于慢性疼痛条件下大脑可塑性的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dynamics of Lateral Habenula–Ventral Tegmental Area Microcircuit on Pain-Related Cognitive Dysfunctions
Chronic pain is a health problem that affects the ability to work and perform other activities, and it generally worsens over time. Understanding the complex pain interaction with brain circuits could help predict which patients are at risk of developing central dysfunctions. Increasing evidence from preclinical and clinical studies suggests that aberrant activity of the lateral habenula (LHb) is associated with depressive symptoms characterized by excessive negative focus, leading to high-level cognitive dysfunctions. The primary output region of the LHb is the ventral tegmental area (VTA), through a bidirectional connection. Recently, there has been growing interest in the complex interactions between the LHb and VTA, particularly regarding their crucial roles in behavior regulation and their potential involvement in the pathological impact of chronic pain on cognitive functions. In this review, we briefly discuss the structural and functional roles of the LHb–VTA microcircuit and their impact on cognition and mood disorders in order to support future studies addressing brain plasticity during chronic pain conditions.
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来源期刊
Neurology International
Neurology International CLINICAL NEUROLOGY-
CiteScore
3.70
自引率
3.30%
发文量
69
审稿时长
11 weeks
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