SYNTHESIS, CHARACTERIZATION AND ANTICANCER STUDIES OF NEWFANGLED INDIUM (III) SCHIFF BASE METAL COMPLEXES

The newfangled Schiff base ligand 2-{[4-(4’- amino-phenoxy)- phenylimino]-methyl}-phenol [HL 1 ], 2-{[4-(4’- amino-phenoxy)- phenylimino]-methyl}- naphthalene-2-ol [HL 2 ], 2-{[4-(4’- amino-phenoxy)- phenylimino]- methyl}- 4 - bromophenol [HL 3 ] and 2-{[4-(4’- amino-phenoxy)- phenylimino]-methyl}-6- methoxyphenol [HL 4 ] and it’s In(III) metal complexes had been synthesized. The ligand and metal complexes have been characterized with elemental analysis, UV-visible, IR, 1 H NMR spectroscopy, thermal studies, and magnetic susceptibility measurement. The crystallographic investigation reveals the tetragonal geometry of In (III) complexes of Schiff bases HL 1 to HL 4 . Also, the magnetic moment and electronic spectral studies supported the tetrahedral structure In (III) complexes of Schiff bases. The antibacterial and antifungal activity of the Schiff base was accentuated while being coordinated with metal ions. Ligand [HL 1-4 ] is immune to both human cancer cell lines, comprehensive of breast (MCF7) and colon (HT29) with GI50 of 62.2 μM, 65.2 μM, 72.2 μM, and 84 μM respectively. In (III) metal complexes confirm adequate activity in the breast (MCF7) cellular cell line with IC50 values of 31.1 μM.