{"title":"β -分泌酶-1酶抑制剂治疗阿尔茨海默病的疗效","authors":"Roohallah Yousefi, Shahla Mokarmian, Ali Jamshidi","doi":"10.21608/aprh.2023.230890.1234","DOIUrl":null,"url":null,"abstract":"Background and Objectives: A number of BACE1 inhibitors have been tested in clinical trials but have been discontinued due to lack of efficacy or unacceptable side effects. In this study, we investigate the physicochemical properties of some of these ligands and their binding affinity for the molecular model of the BACE1 enzyme [PDB ID:","PeriodicalId":15017,"journal":{"name":"Journal of Advanced Pharmacy Research","volume":"54 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Efficacy of Beta-Secretase-1 Enzyme Inhibitors in Alzheimer's Disease\",\"authors\":\"Roohallah Yousefi, Shahla Mokarmian, Ali Jamshidi\",\"doi\":\"10.21608/aprh.2023.230890.1234\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background and Objectives: A number of BACE1 inhibitors have been tested in clinical trials but have been discontinued due to lack of efficacy or unacceptable side effects. In this study, we investigate the physicochemical properties of some of these ligands and their binding affinity for the molecular model of the BACE1 enzyme [PDB ID:\",\"PeriodicalId\":15017,\"journal\":{\"name\":\"Journal of Advanced Pharmacy Research\",\"volume\":\"54 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Advanced Pharmacy Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21608/aprh.2023.230890.1234\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Advanced Pharmacy Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21608/aprh.2023.230890.1234","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Efficacy of Beta-Secretase-1 Enzyme Inhibitors in Alzheimer's Disease
Background and Objectives: A number of BACE1 inhibitors have been tested in clinical trials but have been discontinued due to lack of efficacy or unacceptable side effects. In this study, we investigate the physicochemical properties of some of these ligands and their binding affinity for the molecular model of the BACE1 enzyme [PDB ID:
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