心血管系统中的硫化氢:一种具有治疗潜力的小分子

Q3 Biochemistry, Genetics and Molecular Biology
Irina Tikhomirova, Alexei Muravyov
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引用次数: 0

摘要

本文综述了硫化氢在心血管系统中的作用、可能的作用机制及其在心血管疾病治疗中的应用前景。硫化氢是近年来公认的一种气体递质,是一种自由穿透细胞膜并调节多种生物功能的简单信号分子。在人体中,内源性H2S通过酶促和非酶促途径产生,其含量在不同组织中存在差异,并受到严格调控。在心血管系统中,H2S由心肌、血管和血细胞产生,并调节许多重要功能。大量实验数据证明,内源性和外源性给药的H2S在心血管系统中具有广泛的作用,包括血管扩张/血管收缩作用、调节血压、血管平滑肌细胞的促凋亡和抗增殖作用、影响血管生成和红细胞生成、缺血-再灌注损伤中的心肌细胞保护、氧传感、抑制血小板聚集和血液凝固等。红细胞微流变特性的改变(聚集性和变形性)。了解H2S作用的分子机制以及H2S、NO和CO之间的分子串扰对于开发其诊断和治疗潜力至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hydrogen sulfide in the cardiovascular system: A small molecule with promising therapeutic potential
This review summarizes current knowledge of the hydrogen sulfide role in cardiovascular system, the proposed mechanisms of its action and the prospects for its applicability in the treatment of cardiovascular diseases. Hydrogen sulfide was recently recognized as gasotransmitter –simple signaling molecule which freely penetrates the cell membrane and regulates a number of biological functions. In humans endogenous H2S is generated via enzymatic and non-enzymatic pathways and its content varies in different tissues and is strictly regulated. In cardiovascular system H2S is produced by myocardial, vascular and blood cells and regulates a number of vital functions. Numerous experimental data prove that endogenously generated as well as exogenously administered H2S exerts a wide range of actions in cardiovascular system, including vasodilator/vasoconstrictor effects, regulation of blood pressure, pro-apoptotic and anti-proliferative effects in the vascular smooth muscle cells, influence on angiogenesis and erythropoiesis, myocardial cytoprotection in ischemia-reperfusion injury, oxygen sensing, inhibition of platelet aggregation and blood coagulation, modification of erythrocyte microrheological properties (aggregability and deformability). Understanding of molecular mechanisms of H2S action and molecular crosstalk between H2S, NO, and CO is essential for the development of its diagnostic and therapeutic potential.
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来源期刊
Journal of Cellular Biotechnology
Journal of Cellular Biotechnology Biochemistry, Genetics and Molecular Biology-Biotechnology
CiteScore
0.70
自引率
0.00%
发文量
13
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