过氧化物酶体增殖物激活受体在肝脏疾病中的作用综述

IF 3.1 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Journal of Clinical and Translational Hepatology Pub Date : 2023-11-15 DOI:10.14218/jcth.2023.00334

Zahra Changizi, Forough Kajbaf, Azam Moslehi

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引用次数: 0

摘要

过氧化物酶体增殖物激活受体(PPARs)是一个核转录受体超家族，由PPARα、PPARγ和PPARβ/δ组成，在肝脏中高度表达。它们控制和调节大量参与肝脏代谢和能量稳态、氧化应激、炎症甚至细胞凋亡的基因的表达。因此，它们在肝脏疾病的病理生理中具有重要作用。本文综述了ppar在肝脏疾病中的作用及其一些激动剂的临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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An Overview of the Role of Peroxisome Proliferator-activated Receptors in Liver Diseases

Peroxisome proliferator-activated receptors (PPARs) are a superfamily of nuclear transcription receptors, consisting of PPARα, PPARγ, and PPARβ/δ, which are highly expressed in the liver. They control and modulate the expression of a large number of genes involved in metabolism and energy homeostasis, oxidative stress, inflammation, and even apoptosis in the liver. Therefore, they have critical roles in the pathophysiology of hepatic diseases. This review provides a general insight into the role of PPARs in liver diseases and some of their agonists in the clinic.

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来源期刊

Journal of Clinical and Translational Hepatology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

6.40

自引率

2.80%

发文量

496