CD4+ T辅助性17与T细胞免疫球蛋白和粘蛋白结构域3之间的平衡参与房颤的发病和发展

IF 0.8 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

African Health Sciences Pub Date : 2023-10-11 DOI:10.4314/ahs.v23i3.71

Wenjing Dai, Jun Zhang, Yang Wang, Jingqun Zhou, Qiuting Dai, Jianfeng Lv

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引用次数: 0

摘要

背景:探讨心房颤动(AF)患者Th17、T淋巴细胞免疫球蛋白粘蛋白3 (TIM-3+)细胞及其相关细胞因子的表达及临床意义。方法:将90例房颤患者分为阵发性组(n=45)和慢性组(n=45)，选取健康志愿者45例作为对照组。检测外周血中Th17细胞和Tim-3 +细胞的比例。测定外周血相关细胞因子的浓度。分析了enth17 / Tim-3+细胞与相关细胞因子的相关性。结果:与对照组相比，阵发性和慢性心房颤动患者外周血Th17细胞比例及相关细胞因子(IL-17、il -6、基质金属蛋白酶(MMP9))浓度显著升高，tim3 +细胞比例及相关细胞因子浓度显著降低。与发作组比较，慢性组患者外周血Th17细胞比例及相关细胞因子浓度显著升高，tim3 +细胞比例及相关细胞因子浓度显著降低。结论:Th17 / Tim-3 +细胞平衡参与房颤，可作为房颤治疗的靶点。关键词:心房颤动;Th17细胞;Tim-3;细胞因子;IL-17;Gal-9。

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The balance between CD4+ T helper 17 and T-cell immunoglobulin and mucin domain 3 is involved in the pathogenesis and development of atrial fibrillation

Background: To investigate the expression of Th17, T lymphocyte immunoglobulin mucin 3 (TIM-3+) cells and their relatedcytokines in atrial fibrillation (AF) and their clinical significance. Methodology: A total of 90 patients with AF were divided into paroxysmal group (n=45) and chronic group (n=45), and 45healthy volunteers were selected as the control group. The proportion of Th17 cells and Tim-3 + cells in the peripheral bloodwere detected. The concentrations of related cytokines in peripheral blood serum were determined. The correlation betweenTh17 / Tim-3+ cells and related cytokines was analysed. Results: Compared with the control group, the proportion of Th17 cells and the concentration of related cytokines (IL-17, IL-6and Matrix metalloproteinase (MMP9)) in peripheral blood of patients with paroxysmal and chronic AF increased significantly,while the proportion of tim3 + cells and the concentration of related cytokines decreased significantly. Compared with theparoxysmal group, the proportion of Th17 cells and the concentration of related cytokines in the peripheral blood of patientsin the chronic group increased significantly, while the proportion of tim3 + cells and the concentration of related cytokinesdecreased significantly. Conclusion: Th17 / Tim-3 + cell balance is involved in AF, and can be used as a target for AF treatment. Keywords: Atrial fibrillation; Th17 cells; Tim-3; Cytokines; IL-17; Gal-9.

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来源期刊

African Health Sciences MEDICINE, GENERAL & INTERNAL-

CiteScore

2.30

自引率

0.00%

发文量

179

审稿时长

>12 weeks

期刊介绍： The African Health Sciences is an internationally refereed journal publishing original articles on research, clinical practice, public health, policy, planning, implementation and evaluation, in the health and related sciences relevant to Africa and the tropics. Its objectives are to: Advocate for and promote the growth of reading culture in sub Saharan Africa; Provide a high quality journal in which health and policy and other researchers and practitioners in the region can and world wide, can publish their work; Promote relevant health system research and publication in the region including alternative means of health care financing, the burden of and solution of health problems in marginalized urban and rural communities amongst the displaced and others affected by conflict; Promote research and the systematic collection and collation and publication of data on diseases and conditions of equity and influence; Promote development of evidence-based policies and guidelines for clinical, public health and other practitioners. African Health Sciences acknowledges support provided by the African Health Journals Partnership Project that is funded by the US National Institutes of Health (through the National Library of Medicine and the Fogarty International Center) and facilitated by the Council of Science Editors.