尼日利亚上皮性卵巢癌中雌激素受体、孕激素受体和人表皮生长因子受体-2过表达的临床病理模式

IF 0.8 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

African Health Sciences Pub Date : 2023-10-11 DOI:10.4314/ahs.v23i3.29

Mustapha Akanji Ajani, Aliyu Lawan, Temitope Oke, Galina Khramtsova, Ifeanyichukwu Nwanji, Ayodeji Salami, Olutosin Awolude, Henry Ebili, Michael E Onwukamuche, Elisabeth Sveen, Toshio Yoshimatsu, Olufunmilayo I Olopade

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引用次数: 0

摘要

背景:卵巢癌是所有妇科恶性肿瘤中死亡的主要原因。迄今为止，在尼日利亚患者中仅研究了少数上皮性卵巢癌(EOC)预后的生物标志物。目的:探讨尼日利亚地区EOC患者雌激素受体(ER)、孕激素受体(PR)和人表皮生长因子受体2 (HER-2)的表达规律;材料和方法:这是一项对102例上皮性卵巢癌的回顾性多中心研究。从3个参与中心的医院记录中获得了相关的临床信息。使用代表性肿瘤组织构建组织微阵列，并在美国芝加哥大学进行ER、PR和HER2免疫组织化学染色。结果:浆液性癌占多数(71%)。ER阳性占31.4%，PR阳性占21.5%，HER2/neu阳性占16.7%。52%的肿瘤呈三阴性。浆液性肿瘤与ER阳性显著相关(p=0.001)。EOC患者的平均年龄为52.6±13.1岁。激素受体状态与组织学分级、FIGO分期或生存率无统计学意义。结论:浆液性肿瘤与ER表达显著相关，而非浆液性肿瘤倾向于三阴性。关键词:雌激素受体;孕激素受体;her - 2过表达;上皮性卵巢癌。

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Clinicopathological pattern of oestrogen receptor, progesterone receptor and human epidermal growth factor receptor-2 over-expression of epithelial ovarian carcinomas in Nigeria

Background: Ovarian cancer is the leading cause of death from all gynaecological malignancies. Only few biomarkers of epithelial ovarian cancer (EOC) prognosis have been studied so far among Nigerian patients. Objective: To determine the pattern of oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER-2) expression in patients with EOC seen in Nigeria Materials and Methods: This was a retrospective multicentre study of 102 cases of epithelial ovarian cancers. Relevant clinical information was obtained from hospital-based records in the 3 participating centres. Tissue microarrays were constructed using representative tumour tissue and the ER, PR and HER2 immunohistochemical staining was carried out at the University of Chicago, United States of America. Results: Serous carcinomas predominated (71% of cases). ER positivity was observed in 31.4%, PR positivity in 21.5% and HER2/neu in 16.7% of tumours. Fifty-two percent of tumours were triple negative. Serous tumours were significantly associated with ER positivity (p=0.001). Mean patient age for EOC was 52.6 ± 13.1 years. There were no statistically significant associations between hormone receptor status and histological grade, FIGO staging or survival. Conclusion: Serous tumours were significantly associated with ER expression while non-serous tumours tended to be triple negative. Keywords: Oestrogen receptor; Progesterone receptor; HER-2 over-expression; Epithelial ovarian cancer.

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来源期刊

African Health Sciences MEDICINE, GENERAL & INTERNAL-

CiteScore

2.30

自引率

0.00%

发文量

179

审稿时长

>12 weeks

期刊介绍： The African Health Sciences is an internationally refereed journal publishing original articles on research, clinical practice, public health, policy, planning, implementation and evaluation, in the health and related sciences relevant to Africa and the tropics. Its objectives are to: Advocate for and promote the growth of reading culture in sub Saharan Africa; Provide a high quality journal in which health and policy and other researchers and practitioners in the region can and world wide, can publish their work; Promote relevant health system research and publication in the region including alternative means of health care financing, the burden of and solution of health problems in marginalized urban and rural communities amongst the displaced and others affected by conflict; Promote research and the systematic collection and collation and publication of data on diseases and conditions of equity and influence; Promote development of evidence-based policies and guidelines for clinical, public health and other practitioners. African Health Sciences acknowledges support provided by the African Health Journals Partnership Project that is funded by the US National Institutes of Health (through the National Library of Medicine and the Fogarty International Center) and facilitated by the Council of Science Editors.