Effects of interventional vascular embolization at different timing on prognosis and serum S100 calcium-binding protein B level of patients with aneurysmal subarachnoid hemorrhage

Objective: To evaluate the effects of interventional vascular embolization at different timing on the prognosis and serum S100calcium-binding protein B (S100B) level of patients with aneurysmal subarachnoid hemorrhage (aSAH). Methods: A total of 229 aSAH patients enrolled from January 2016 to January 2020 were divided into an early-stage group(n=66), a middle-stage group (n=95) and a late-stage group (n=68. Their baseline data, serum indices and clinical outcomes werecompared. The factors affecting their prognosis were analysed. The value of serum S100B level for predicting the prognosis wasevaluated. Results: The early-stage group had the highest GOS score, and the late-stage group had the lowest score (P<0.05). Older age,large diameter of aneurysm, high Hunt-Hess grade upon admission, late surgical treatment and high S100B level were risk factorsfor the poor prognosis of aSAH patients. The optimal cut-off value of S100B for predicting the prognosis was 2.785 μg/L.The area under the receiver operator characteristic curve, sensitivity, specificity, Youden index and 95% confidence interval were0.892, 84.3%, 86.3%, 0.706 and 0.844-0.940, respectively. Conclusion: Early vascular interventional embolization is beneficial to the alleviation of brain injury and the reduction of serumS100B level. Keywords: Aneurysmal subarachnoid hemorrhage; interventional vascular embolization; prognosis; S100 calcium-binding proteinB; timing.