替代支架类放射性药物[<sup>99m</sup>Tc]Tc- adapt6与[<sup>99m</sup>Tc]Tc-(HE)<sub>3</sub>- g3对her2阳性乳腺癌患者诊断效果的直接比较

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL
O. D. Bragina, S. M. Deyev, E. Yu. Garbukov, V. E. Goldberg, V. I. Chernov, V. M. Tolmachev
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引用次数: 0

摘要

的目标。直接比较[99m Tc]Tc- adapt6和[99m Tc]Tc-(HE) - g3在全身治疗前对her2阳性乳腺癌患者的诊断效果。材料和方法。该研究纳入了11例开始全身治疗前的her2阳性乳腺癌患者(T1-4N0-2M0-1)。所有患者均行[99m Tc]TcADAPT6和[99m Tc]Tc-(HE) - g3放射性核素检查,间隔时间为3-4天。单光子发射计算机断层扫描(SPECT) /计算机断层扫描(CT)分别在[99m Tc]Tc- adapt6和[99m Tc]Tc(HE) 3 -G3给药后2和4小时进行。结果。[99m Tc]Tc- adapt6和[99m Tc]Tc-(HE) - g3分布分析显示其在肾脏和肝脏的高摄取。所有病例均可见乳腺肿瘤。[99mTc]Tc- adapt6的平均肿瘤摄取为4.7±2.1,显著高于[99mTc]Tc-(HE)3-G3注射组(3.5±1.7)(p <0.005,配对t检验)。肿瘤与背景比(分别为15.2±7.4和19.6±12.4)在两例中无统计学差异(p >0.05,配对t检验)。患者1和5均可见肝转移灶,与腹部CT增强扫描的转移灶投影相对应。[99m Tc]Tc- adapt6和[99m Tc]Tc-(HE)3-G3在两例转移灶投射中的积累均明显高于原发肿瘤(患者1高1.3倍和1.7倍;患者5分别高出2.2倍和3.5倍)。结论。[99m Tc]Tc- adapt6和[99m Tc]Tc-(HE)3-G3在乳腺癌患者中显示原发性her2阳性肿瘤的诊断效果。但[99mTc]Tc-ADEPT6具有较高的积累值,使其成为更有前景的诊断药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A direct comparison of the diagnostic efficacy of alternative scaffoldbased radiopharmaceuticals [<sup>99m</sup>Tc]Tc-ADAPT6 and [<sup>99m</sup>Tc]Tc-(HE)<sub>3</sub>-G3 in patients with HER2-positive breast cancer
Aim. To perform a direct comparison of the diagnostic efficacy of [ 99m Tc]Tc-ADAPT6 and [ 99m Tc]Tc-(HE) -G3 in HER2-positive breast cancer patients before the systemic treatment. Materials and methods. The study included 11 patients with HER2-positive breast cancer (T1–4N0–2M0–1) before the initiation of systemic treatment. All patients underwent a radionuclide examination with [ 99m Tc]TcADAPT6 and [ 99m Tc]Tc-(HE) -G3 with the interval of 3–4 days. Single-photon emission computed tomography (SPECT) /computed tomography (CT) was performed 2 and 4 hours after [ 99m Tc]Tc-ADAPT6 and [ 99m Tc]Tc(HE) 3 -G3 administration, respectively. Results. The analysis of [ 99m Tc]Tc-ADAPT6 and [ 99m Tc]Tc-(HE) -G3 distribution showed their high uptake in the kidneys and liver. Breast tumors were visualized in all cases. The average tumor uptake of [99mTc]Tc-ADAPT6 was 4.7 ± 2.1, which was significantly higher than in the [99mTc]Tc-(HE)3-G3 injection (3.5 ± 1.7) (p < 0.005, paired t-test). The tumor-to-background ratio (15.2 ± 7.4 and 19.6 ± 12.4, respectively) had no statistical differences in both cases (p > 0.05, paired t-test). Liver metastases were visualized in patients 1 and 5 and corresponded to the projection of metastases according to contrast-enhanced abdominal CT. The accumulation of [ 99m Tc]Tc-ADAPT6 and [ 99m Tc]Tc-(HE)3-G3 in the projection of metastases in both cases was significantly higher compared to the primary tumor (1.3 and 1.7 times higher in patient 1; 2.2 and 3.5 times higher in patient 5, respectively). Conclusion. Both [ 99m Tc]Tc-ADAPT6 and [ 99m Tc]Tc-(HE)3-G3 demonstrated the diagnostic efficacy in visualizing a primary HER2-positive tumor in breast cancer patients. However, [99mTc]Tc-ADEPT6 had higher accumulation values, which makes it a more promising diagnostic agent.
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来源期刊
Byulleten Sibirskoy Meditsiny
Byulleten Sibirskoy Meditsiny MEDICINE, GENERAL & INTERNAL-
CiteScore
0.70
自引率
50.00%
发文量
102
审稿时长
8 weeks
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