Radmila Glišić, Maja Čakić-Milošević, Mirela Ukropina, Stefan Marković, Marija Marin, Vesna Stanković
{"title":"地塞米松治疗大鼠胃黏膜分泌胃泌素的G细胞","authors":"Radmila Glišić, Maja Čakić-Milošević, Mirela Ukropina, Stefan Marković, Marija Marin, Vesna Stanković","doi":"10.5937/kgjsci2345195g","DOIUrl":null,"url":null,"abstract":"The systemic administration of glucocorticoids has not only strong beneficial anti-inflammatory and immunosuppressive effects but also numerous adverse health effects. Therefore, this study aimed to investigate the stereological and ultrastructural characteristics and distribution of gastrin-producing G cells in rat antral mucosa after 12 days of intraperitoneal administration of 2 mg/kg dexamethasone (DEX). In both groups of rats (DEX and control), the G cells were located at the base of the antral mucosal crypts, but in the DEX-treated rats, they were also found near the gastric lumen and showed an altered morphology compared to the basal cells. There were significant differences in the number of G cells per unit area and unit volume of antral mucosa between the groups studied. In the DEX-treated rats, the modified morphology and position of the antral G cells within the gastric units indicate their modified activity and possible impaired regulation of gastric acid production.","PeriodicalId":17829,"journal":{"name":"Kragujevac Journal of Science","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Gastrin-producing G cells of gastric mucosa in Dexamethasone-treated rats\",\"authors\":\"Radmila Glišić, Maja Čakić-Milošević, Mirela Ukropina, Stefan Marković, Marija Marin, Vesna Stanković\",\"doi\":\"10.5937/kgjsci2345195g\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The systemic administration of glucocorticoids has not only strong beneficial anti-inflammatory and immunosuppressive effects but also numerous adverse health effects. Therefore, this study aimed to investigate the stereological and ultrastructural characteristics and distribution of gastrin-producing G cells in rat antral mucosa after 12 days of intraperitoneal administration of 2 mg/kg dexamethasone (DEX). In both groups of rats (DEX and control), the G cells were located at the base of the antral mucosal crypts, but in the DEX-treated rats, they were also found near the gastric lumen and showed an altered morphology compared to the basal cells. There were significant differences in the number of G cells per unit area and unit volume of antral mucosa between the groups studied. In the DEX-treated rats, the modified morphology and position of the antral G cells within the gastric units indicate their modified activity and possible impaired regulation of gastric acid production.\",\"PeriodicalId\":17829,\"journal\":{\"name\":\"Kragujevac Journal of Science\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Kragujevac Journal of Science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5937/kgjsci2345195g\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Kragujevac Journal of Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5937/kgjsci2345195g","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Gastrin-producing G cells of gastric mucosa in Dexamethasone-treated rats
The systemic administration of glucocorticoids has not only strong beneficial anti-inflammatory and immunosuppressive effects but also numerous adverse health effects. Therefore, this study aimed to investigate the stereological and ultrastructural characteristics and distribution of gastrin-producing G cells in rat antral mucosa after 12 days of intraperitoneal administration of 2 mg/kg dexamethasone (DEX). In both groups of rats (DEX and control), the G cells were located at the base of the antral mucosal crypts, but in the DEX-treated rats, they were also found near the gastric lumen and showed an altered morphology compared to the basal cells. There were significant differences in the number of G cells per unit area and unit volume of antral mucosa between the groups studied. In the DEX-treated rats, the modified morphology and position of the antral G cells within the gastric units indicate their modified activity and possible impaired regulation of gastric acid production.