2015-2019年俄罗斯联邦登记的儿童急性弛缓性脊髓炎的临床和流行病学特征

Q4 Medicine
A. K. Shakaryan, I. Kh. Belyaletdinova, S. V. Shakhgildyan, O. E. Ivanova, T. P. Eremeeva, A. P. Gmyl, O. Yu. Baykova, A. N.-I. Mustafina, L. I. Kozlovskaya
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引用次数: 0

摘要

急性弛缓性脊髓炎是一种综合征,其特征是由于脊髓前角的病变而发展为一个或多个肢体的急性弛缓性麻痹,这是在病毒感染的背景下发生的。俄罗斯联邦每年登记的急性弛缓性麻痹病例超过300例,其中大多数是非传染性病因。在某些情况下,患者出现类似于脊髓灰质炎的复杂症状,但没有从粪便样本中分离脊髓灰质炎病毒。这类病例的临床特征包括急性发病、发热、持续外周非对称性麻痹/肢体主要近端瘫痪、无病理性反射、盆腔紊乱或锥体症状。在文献中,这种复杂的症状被称为急性弛缓性脊髓炎。我们对2015年至2019年在俄罗斯联邦检测到的18例急性弛缓性脊髓炎进行了分析。注意到该病在7月至11月有明显的季节性。对粪便样本、脑脊液和血液样本的研究未发现病原体。在所有患者中,无论采用何种治疗方法,都有积极的趋势,但没有实现完全恢复:不同程度的麻痹持续存在,主要在近端。因此,急性弛缓性脊髓炎病例作为病因不明的急性弛缓性麻痹病例,需要额外的观察和扩展的实验室调查算法,以寻找可能的病原体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical and epidemiological characteristics of acute flaccid myelitis cases in children registered in the Russian Federation in 2015–2019
Acute flaccid myelitis is a syndrome characterized as the development of acute flaccid paralysis of one or more limbs due to lesions of the anterior horns of the spinal cord, which occurs against the background of a viral infection. More than 300 acute flaccid paralysis cases are registered in the Russian Federation annually, most of them are of a non-infectious etiology. In some cases, patients develop a complex of symptoms similar to poliomyelitis, but without isolation of polioviruses from stool samples. Clinical characteristics of such cases include acute onset, fever, persistent peripheral asymmetric paresis/paralysis of predominantly proximal parts of the limbs, and absence of pathological reflexes, pelvic disturbances, or pyramidal symptoms. In literature, such complex of symptoms is referred as acute flaccid myelitis. We provide an analysis of 18 cases of acute flaccid myelitis detected in the Russian Federation in the period from 2015 to 2019. A clear seasonality of the disease from July to November was noted. Studies of faecal samples, cerebrospinal fluid and blood samples did not reveal the pathogen. In all patients, regardless of therapy, there was a positive trend, but complete recovery was not achieved: paresis of varying severity persisted, mainly in the proximal extremities Therefore, acute flaccid myelitis cases as acute flaccid paralysis cases of unknown etiology require an additional observation and an expanded algorithm of laboratory investigation aimed to finding a possible pathogen.
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来源期刊
Nervno-Myshechnye Bolezni
Nervno-Myshechnye Bolezni Medicine-Neurology (clinical)
CiteScore
0.50
自引率
0.00%
发文量
20
审稿时长
8 weeks
期刊介绍: The principal objective of the "Neuromuscular Diseases" journal is publication of state-of-art information about scientific clinical studies, diagnostics, and treatment of neurological diseases. "Neuromuscular Diseases" is a peer-reviewed journal, and members of its editorial board are major professionals in Russia and the CIS countries that have deserved authority not only in our country but abroad as well. Besides, leading scientists of Europe and the USA regularly cooperate with the journal. The journal regularly publishes reviews of modern literature references, proprietary clinical observations, lectures, original articles, results of research protocols in various areas of neuromuscular pathology - clinical presentation, diagnostics, medication, surgical and non-drug therapies, modern trends in drug rehabilitation, and recent drug developments. Due to international cooperation, the journal contains the newest therapeutic and diagnostic approaches to monitoring of patients with neuromuscular pathology.
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