Nrf2在非酒精性脂肪性肝病中的作用机制及相关天然调节因子

IF 2.8 4区医学 Q2 PHARMACOLOGY & PHARMACY

Current drug delivery Pub Date : 2023-10-30 DOI:10.2174/0115672018260113231023064614

Wenfei Yu, Decheng Meng, Xin Zhang, Yanan Feng, Guoliang Yin, Pengpeng Liang, Suwen Chen, Hongshuai Liu, Fengxia Zhang

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引用次数: 0

摘要

摘要:随着人们生活节奏的加快，非酒精性脂肪性肝病(NAFLD)已成为世界上最常见的慢性肝病，极大地威胁着人们的健康和安全。因此，在这一领域仍迫切需要更高质量的研究和治疗。核因子Red-2-related factor 2 (Nrf2)作为调控氧化应激的关键转录因子，在诱导机体抗氧化反应中起着重要作用。虽然目前尚无批准的靶向Nrf2治疗NAFLD的药物，但靶向Nrf2缓解NAFLD仍具有重要意义。近年来，有研究报道许多天然产物通过作用于Nrf2或Nrf2通路来治疗NAFLD。本文综述了Nrf2在NAFLD发病机制中的作用，并对目前报道的靶向Nrf2或Nrf2通路治疗NAFLD的天然产物进行了总结，为开发新的NAFLD相关药物提供了新的思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Mechanism of Action and Related Natural Regulators of Nrf2 in Nonalcoholic Fatty Liver Disease

Abstract:: With the acceleration of people's pace of life, non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease in the world, which greatly threatens people's health and safety. Therefore, there is still an urgent need for higher-quality research and treatment in this area. Nuclear factor Red-2-related factor 2 (Nrf2), as a key transcription factor in the regulation of oxidative stress, plays an important role in inducing the body's antioxidant response. Although there are no approved drugs targeting Nrf2 to treat NAFLD so far, it is still of great significance to target Nrf2 to alleviate NAFLD. In recent years, studies have reported that many natural products treat NAFLD by acting on Nrf2 or Nrf2 pathways. This article reviews the role of Nrf2 in the pathogenesis of NAFLD and summarizes the currently reported natural products targeting Nrf2 or Nrf2 pathway for the treatment of NAFLD, which provides new ideas for the development of new NAFLD-related drugs.

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来源期刊

Current drug delivery PHARMACOLOGY & PHARMACY-

CiteScore

5.10

自引率

4.20%

发文量

170

期刊介绍： Current Drug Delivery aims to publish peer-reviewed articles, research articles, short and in-depth reviews, and drug clinical trials studies in the rapidly developing field of drug delivery. Modern drug research aims to build delivery properties of a drug at the design phase, however in many cases this idea cannot be met and the development of delivery systems becomes as important as the development of the drugs themselves. The journal aims to cover the latest outstanding developments in drug and vaccine delivery employing physical, physico-chemical and chemical methods. The drugs include a wide range of bioactive compounds from simple pharmaceuticals to peptides, proteins, nucleotides, nucleosides and sugars. The journal will also report progress in the fields of transport routes and mechanisms including efflux proteins and multi-drug resistance. The journal is essential for all pharmaceutical scientists involved in drug design, development and delivery.