黏液表皮样癌:角蛋白、S-100蛋白、乳铁蛋白、溶菌酶和淀粉酶的免疫组化研究。

Basic and applied histochemistry Pub Date : 1988-01-01
S Kumasa, R Yuba, S Sagara, T Okutomi, Y Okada, M Mori
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引用次数: 0

摘要

8例黏液表皮样癌(G-I, 3例;G-II, 2例;和G-III, 3例)显示所检查的蛋白质具有明显的异质性。免疫组织化学检测到的角蛋白(TK、KL1和PKK1)分布在表皮样细胞中,但在粘液分泌细胞中不存在。在G-I肿瘤的鳞状肿瘤细胞中检测到强烈阳性的角蛋白沉积。肿瘤细胞显示S-100 α阳性,但多克隆S-100抗血清或单克隆S-100 β未染色。对S-100蛋白反应活性最高的细胞分散在肿瘤灶内,可能是朗格汉斯细胞。肿瘤灶内乳铁蛋白和溶菌酶反应普遍为阴性;但在管腔肿瘤细胞中发现乳铁蛋白阳性反应,尽管很少,偶尔在基质组织细胞中发现溶菌酶染色。淀粉酶活性在肿瘤细胞中通常不存在,只有一个病例的淀粉酶活性局限于肿瘤细胞。不同级别的黏液表皮样癌在各种免疫组织化学检测蛋白方面表现出明显的异质性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mucoepidermoid carcinomas: immunohistochemical studies on keratin, S-100 protein, lactoferrin, lysozyme and amylase.

Immunohistochemical expression of 8 cases of mucoepidermoid carcinomas (G-I, 3 cases; G-II, 2 cases; and G-III, 3 cases) revealed marked heterogeneity of the proteins examined. Immunohistochemically detectable keratins (TK, KL1, and PKK1) were distributed in epidermoid cells, but were absent in mucous secreting cells. Strongly positive deposits of keratin proteins were detected in squamoid tumor cells in the G-I tumors. The tumor cells displayed positive staining for S-100 alpha, but did not stain with polyclonal S-100 antiserum or with monoclonal S-100 beta. The cells showing highest reactivity for S-100 protein were scattered in neoplastic foci and were probably Langerhans cells. Lactoferrin and lysozyme reactions were generally negative in tumor foci; but a positive reaction for lactoferrin was found in luminal tumor cells although rarely, and lysozyme staining was occasionally noted in histiocytes in the stroma. Amylase activity was usually absent in the tumor cells, with the exception of one case in which it was confined to the tumor cells. Mucoepidermoid carcinomas of various grades indicated marked heterogeneity in terms of various immunohistochemically detectable proteins.

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