年轻动脉高血压患者的代谢激素水平与腹部肥胖的关系

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL
Ya. V. Polonskaya, E. V. Kashtanova, E. M. Stakhneva, V. S. Shramko, E. V. Sadovski, S. R. Ledovskikh, L. V. Shcherbakova, E. V. Garbuzova, A. D. Khudyakova, Yu. I. Ragino
{"title":"年轻动脉高血压患者的代谢激素水平与腹部肥胖的关系","authors":"Ya. V. Polonskaya, E. V. Kashtanova, E. M. Stakhneva, V. S. Shramko, E. V. Sadovski, S. R. Ledovskikh, L. V. Shcherbakova, E. V. Garbuzova, A. D. Khudyakova, Yu. I. Ragino","doi":"10.20538/1682-0363-2023-3-74-79","DOIUrl":null,"url":null,"abstract":"Aim. To study the level of metabolic hormones in young people with arterial hypertension (AH) against the background of abdominal obesity (AO). Materials and methods. The study included 498 people who were divided into two groups. The experimental group encompassed 250 people with AH, of which – 159 people had AO, the average systolic pressure – 141.9 ± 13.9 mm Hg, diastolic pressure – 95.6 ± 7.5 mm Hg. The control group included 248 people comparable to the experimental group by gender and age, of whom 104 people had AO, the average systolic pressure – 118.5 ± 9.8 mm Hg, diastolic pressure – 77.8 ± 7.4 mm Hg. The levels of amylin, C-peptide, ghrelin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), glucagon, insulin, pancreatic polypeptide (PP), and peptide YY (PYY) were determined by the multiplex analysis. The level of glucose was determined by the enzymatic method. Statistical processing of the results was carried out using the SPSS 13.0 software. Results. Patients with AH had higher levels of amylin, C-peptide, and glucose and lower levels of PYY. There was no significant difference between the experimental group and the control group for the rest of the studied parameters. In the experimental group, the C-peptide, GLP-1, glucagon, and insulin levels were associated with AO. In the control group, the association of AO with the levels of C-peptide, insulin, and glucose was shown. The odds of AH in people under the age of 45 years were associated with a decrease in the level of PYY, a rise in the amylin levels, and an increase in waist circumference. Conclusion. Of the studied metabolic hormones, an increased level of amylin and reduced PYY can serve as potential biomarkers indicating high odds of developing AH in people under 45 years of age. AO is a factor that contributes to the development of AH at a young age.","PeriodicalId":43691,"journal":{"name":"Byulleten Sibirskoy Meditsiny","volume":"127 1","pages":"0"},"PeriodicalIF":0.2000,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The level of metabolic hormones in young people with arterial hypertension against the background of abdominal obesity\",\"authors\":\"Ya. V. Polonskaya, E. V. Kashtanova, E. M. Stakhneva, V. S. Shramko, E. V. Sadovski, S. R. Ledovskikh, L. V. Shcherbakova, E. V. Garbuzova, A. D. Khudyakova, Yu. I. Ragino\",\"doi\":\"10.20538/1682-0363-2023-3-74-79\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Aim. To study the level of metabolic hormones in young people with arterial hypertension (AH) against the background of abdominal obesity (AO). Materials and methods. The study included 498 people who were divided into two groups. The experimental group encompassed 250 people with AH, of which – 159 people had AO, the average systolic pressure – 141.9 ± 13.9 mm Hg, diastolic pressure – 95.6 ± 7.5 mm Hg. The control group included 248 people comparable to the experimental group by gender and age, of whom 104 people had AO, the average systolic pressure – 118.5 ± 9.8 mm Hg, diastolic pressure – 77.8 ± 7.4 mm Hg. The levels of amylin, C-peptide, ghrelin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), glucagon, insulin, pancreatic polypeptide (PP), and peptide YY (PYY) were determined by the multiplex analysis. The level of glucose was determined by the enzymatic method. Statistical processing of the results was carried out using the SPSS 13.0 software. Results. Patients with AH had higher levels of amylin, C-peptide, and glucose and lower levels of PYY. There was no significant difference between the experimental group and the control group for the rest of the studied parameters. In the experimental group, the C-peptide, GLP-1, glucagon, and insulin levels were associated with AO. In the control group, the association of AO with the levels of C-peptide, insulin, and glucose was shown. The odds of AH in people under the age of 45 years were associated with a decrease in the level of PYY, a rise in the amylin levels, and an increase in waist circumference. Conclusion. Of the studied metabolic hormones, an increased level of amylin and reduced PYY can serve as potential biomarkers indicating high odds of developing AH in people under 45 years of age. AO is a factor that contributes to the development of AH at a young age.\",\"PeriodicalId\":43691,\"journal\":{\"name\":\"Byulleten Sibirskoy Meditsiny\",\"volume\":\"127 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.2000,\"publicationDate\":\"2023-10-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Byulleten Sibirskoy Meditsiny\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.20538/1682-0363-2023-3-74-79\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Byulleten Sibirskoy Meditsiny","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.20538/1682-0363-2023-3-74-79","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0

摘要

的目标。目的:探讨腹型肥胖(AO)背景下年轻人动脉高血压(AH)代谢激素水平的变化。材料和方法。这项研究包括498人,他们被分为两组。实验小组包含250人啊,- 159人AO,平均收缩压- 141.9±13.9毫米汞柱,舒张压- 95.6±7.5毫米汞柱。对照组包括248人与性别和年龄的实验组,其中有104人AO,平均收缩压- 118.5±9.8毫米汞柱,舒张压- 77.8±7.4毫米汞柱。水平的糊精,c -肽、胃饥饿素,glucose-dependent insulinotropic多肽(吉普赛人),多重分析法测定胰高血糖素样肽-1 (GLP-1)、胰高血糖素、胰岛素、胰多肽(PP)、胰肽YY (PYY)。葡萄糖水平用酶法测定。采用SPSS 13.0软件对结果进行统计处理。结果。AH患者胰淀素、c肽和葡萄糖水平较高,PYY水平较低。其余研究参数,实验组与对照组无显著差异。实验组c肽、GLP-1、胰高血糖素和胰岛素水平与AO相关。在对照组中,AO与c肽、胰岛素和葡萄糖水平相关。45岁以下人群患AH的几率与PYY水平的降低、胰淀素水平的升高和腰围的增加有关。结论。在所研究的代谢激素中,amylin水平升高和PYY降低可以作为潜在的生物标志物,表明45岁以下人群患AH的几率很高。AO是导致幼年AH发展的一个因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The level of metabolic hormones in young people with arterial hypertension against the background of abdominal obesity
Aim. To study the level of metabolic hormones in young people with arterial hypertension (AH) against the background of abdominal obesity (AO). Materials and methods. The study included 498 people who were divided into two groups. The experimental group encompassed 250 people with AH, of which – 159 people had AO, the average systolic pressure – 141.9 ± 13.9 mm Hg, diastolic pressure – 95.6 ± 7.5 mm Hg. The control group included 248 people comparable to the experimental group by gender and age, of whom 104 people had AO, the average systolic pressure – 118.5 ± 9.8 mm Hg, diastolic pressure – 77.8 ± 7.4 mm Hg. The levels of amylin, C-peptide, ghrelin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), glucagon, insulin, pancreatic polypeptide (PP), and peptide YY (PYY) were determined by the multiplex analysis. The level of glucose was determined by the enzymatic method. Statistical processing of the results was carried out using the SPSS 13.0 software. Results. Patients with AH had higher levels of amylin, C-peptide, and glucose and lower levels of PYY. There was no significant difference between the experimental group and the control group for the rest of the studied parameters. In the experimental group, the C-peptide, GLP-1, glucagon, and insulin levels were associated with AO. In the control group, the association of AO with the levels of C-peptide, insulin, and glucose was shown. The odds of AH in people under the age of 45 years were associated with a decrease in the level of PYY, a rise in the amylin levels, and an increase in waist circumference. Conclusion. Of the studied metabolic hormones, an increased level of amylin and reduced PYY can serve as potential biomarkers indicating high odds of developing AH in people under 45 years of age. AO is a factor that contributes to the development of AH at a young age.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Byulleten Sibirskoy Meditsiny
Byulleten Sibirskoy Meditsiny MEDICINE, GENERAL & INTERNAL-
CiteScore
0.70
自引率
50.00%
发文量
102
审稿时长
8 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信