一种口服制剂对皮肤美白的影响:在健康的亚洲参与者中进行的一项双盲随机安慰剂对照临床研究的酪氨酸酶体外抑制结果

IF 3.4 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Camille Pouchieu, Line Pourtau, David Gaudout, Ilona Gille, Kunyanatt Chalothorn, Fabrice Perin
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引用次数: 0

摘要

含有天然植物提取物的口服配方代表了一种安全而有前途的美白和抗黑斑策略,特别是在亚洲。本研究评估了富含多酚提取物和维生素C的口服制剂(Belight3TM)对酪氨酸酶体外抑制活性的影响,并研究了其在体内的美白和抗黑斑作用。分光光度法测定其酪氨酸酶抑制活性。一项随机、双盲、安慰剂对照的临床研究对58名年龄在45-65岁的健康亚洲男性和女性进行了研究。在基线、6周和12周用数码照片测量皮肤颜色。用分光光度法测定黑斑的颜色。体外实验结果表明,该制剂对酪氨酸酶的协同抑制活性较对照组显著提高了85%。在体内,口服该制剂12周后,皮肤显着变浅,明显优于安慰剂。此外,该配方在6周和12周后对黑斑有轻微而显著的淡化作用。我们的研究结果表明,在12周内每天口服Belight3TM是一种有效和安全的营养品,可以减轻亚洲受试者面部皮肤的颜色和黑斑。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of an Oral Formulation on Skin Lightening: Results from In Vitro Tyrosinase Inhibition to a Double-Blind Randomized Placebo-Controlled Clinical Study in Healthy Asian Participants
Oral formulations with natural plant-based extracts represent a safe and promising strategy for skin lightening and anti-dark-spot effects, especially in Asia. This study evaluated the effect of an oral formulation including polyphenol-rich extracts and vitamin C (Belight3TM) on in vitro tyrosinase inhibitory activity and investigated its skin lightening and anti-dark-spot effects in vivo. Tyrosinase inhibitory activity of the formulation was measured with spectrophotometry. A randomized, double-blind, placebo-controlled clinical study was carried out on 58 healthy Asian males and females, aged 45–65. Skin color was measured at baseline, 6 weeks and 12 weeks with digital photographs. Color of dark spots was assessed with spectrophotometry. In vitro, the formulation showed a significant synergistic tyrosinase inhibitory activity of 85% compared to the control. In vivo, 12-week oral administration of the formulation significantly lightened the skin and was significantly better than the placebo. In addition, this formulation induced a slight and significant lightening effect of the dark spots after 6 and 12 weeks. Our findings suggest that the daily oral administration of Belight3TM during 12 weeks appears as an efficient and safe nutricosmetic to lighten the color of the facial skin and dark spots in Asian subjects.
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来源期刊
Cosmetics
Cosmetics Medicine-Surgery
CiteScore
5.20
自引率
12.10%
发文量
108
审稿时长
8 weeks
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