儿童和青少年滤泡性淋巴瘤:临床、诊断和治疗特点

Q4 Medicine
T. T. Valiev, A. S. Volkova, M. A. Postoykina, D. S. Abramov, A. R. Karibova, A. A. Odzharova, Yu. E. Ryabukhina, P. A. Zeynalova
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引用次数: 0

摘要

滤泡性淋巴瘤(FL)是成人中最常见的非霍奇金淋巴瘤之一,而在青少年和儿童中是一种排除性的诊断。儿童FL的临床表现为长期无症状的淋巴结病变,较少累及结外区域。儿童滤泡性淋巴瘤的治疗标准尚未制定,可能从观察策略(在活检期间根治性切除单个病灶)到使用放射治疗和综合化疗有所不同。2008年,在世界卫生组织的造血和淋巴组织肿瘤分类中,儿科型滤泡性淋巴瘤首次被确定为一种不同的变体。临床、形态学(3A型细胞学)、免疫组化(卵泡中心缺乏bcl2表达)和细胞遗传学(缺乏t(14;18)(q32;q21))特征是分离成独立的病原学变异的原因。尽管有“儿科”一词,但在30岁以上的成年人中也有儿科型FL的病例。大多数情况下,该疾病在早期阶段(I, II)被诊断出来,其特点是预后良好。在儿童和青少年中,FL不仅发生在儿科类型。我们报告一个17岁患者的典型“成人”型FL(1-2级)的临床病例。cHop治疗(环磷酰胺、阿霉素、长春新碱和强的松龙)联合利妥昔单抗可完全缓解,持续时间超过2.5年。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Follicular lymphoma in children and adolescents: clinical, diagnostic and therapeutic features
Ffollicular lymphoma (FL) is one of the most common non-Hodgkin’s lymphomas in adults, while it is a diagnosis of exclusion in adolescents and children. Clinical manifestations of FL in children are represented by long-term asymptomatic lymphadenopathy, less commonly by extranodal areas involvement. treatment standards for FL in children have not been developed and may vary from observational tactics (with the radical resection of a single focus during a biopsy) to the use of radiation therapy and polychemotherapy. Pediatric type follicular lymphoma was first identified as a distinct variant in 2008 in the world Health organization classification of hematopoietic and lymphoid tissue tumors. Clinical, morphological (cytological type 3A), Immunohistochemical (absence of bcl2 expression in the center of the follicle) and cytogenetic (absence of t(14;18)(q32;q21)) features served as the reason for separation into an independent nosological variant. Despite the term “pediatric”, cases of pediatric type FL have been described in adults over 30 years of age. Most often, the disease is diagnosed in the early stages (I, II) and is characterized by a favorable prognosis. In children and adolescents, FL occurs not only of the pediatric type. we present a clinical case of a typical “adult” type FL (grade 1–2) in a 17-year-old patient. the cHop therapy (cyclophosphamide, doxorubicin, vincristine, and prednisolone) with rituximab resulted in a complete remission, which lasted more than 2.5 years.
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来源期刊
Oncogematologiya
Oncogematologiya Medicine-Hematology
CiteScore
0.50
自引率
0.00%
发文量
67
审稿时长
10 weeks
期刊介绍: The main purpose of the Oncohematology journal is to publish up-to-date information on clinical, experimental and fundamental scientific research, diagnostics and treatment options, as well as other materials on all relevant issues in oncohematology. The journal’s objectives are to inform various specialists who provide advisory and therapeutic assistance to patients with oncohematological diseases about current advances, including the latest methods for the diagnosis and treatment of malignant blood diseases. The journal is an interdisciplinary scientific publication uniting doctors of various specialties ‒ hematologists, oncologists, surgeons, radiation therapists, intensive care specialist, pathologists, etc. ‒ to form an interdisciplinary therapy approach in order to improve the treatment efficacy of patients with hematological malignancies.
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