通过性腺类固醇激素在早产中的免疫耐受和炎症机制

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-10-01 DOI:10.1097/fm9.0000000000000199

Yongmei Shen, Yaqi Li, Jiasong Cao, Wen Li, Qimei Lin, Jianxi Wang, Zhuo Wei, Ying Chang

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引用次数: 0

摘要

2019年，全球约有66万人死于早产(PTB)。肺结核还与新生儿死亡率和长期并发症的风险显著增高有关。长期研究表明，包括免疫耐受破坏和炎症在内的几个因素与肺结核有关。然而，肺结核的发病机制尚不清楚。性腺类固醇激素对维持妊娠和调节免疫和炎症反应至关重要。然而，性腺类固醇激素失衡，如雌激素/雄激素或雌激素/黄体酮失衡如何导致PTB尚不清楚。在这篇综述中，我们讨论了性腺类固醇激素如何介导免疫耐受和炎症反应功能障碍，这是已知的促进PTB发生的因素，并为PTB的预测提供了新的见解。

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Mechanisms of Immune Tolerance and Inflammation via Gonadal Steroid Hormones in Preterm Birth

Abstract In 2019, preterm births (PTB) accounted for approximately 0.66 million deaths globally. PTB is also associated with a significantly higher risk of mortality and long-term complications for newborns. Long-term studies associated several factors, including disruption of immune tolerance and inflammation, with PTB. However, the pathogenesis of PTB remains unclear. Gonadal steroid hormones are critical for pregnancy maintenance and regulation of immune and inflammatory responses. However, it is not clear how unbalanced gonadal steroid hormones, such as imbalanced estrogen/androgen or estrogen/progesterone contribute to PTB. In this review, we discuss how gonadal steroid hormones mediate dysfunction in immune tolerance and inflammatory responses, which are known to promote the occurrence of PTB, and provide insight into PTB prediction.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.