Effects of Resistance Exercise on Older Individuals with Sarcopenia: Sex Differences in Humans

Sarcopenia affects tens of millions of adults worldwide, with a reported prevalence of 10-50% among older adults. A decrease in muscle strength and function due to aging reduces physical performance, causing pain and disease. Accordingly, interest in the treatment or prevention of sarcopenia through resistance exercises, which have been found to be effective in improving muscle strength and hypertrophy, is increasing. However, given the individual differences, it is difficult to determine the optimal RE method. Currently, the importance of personalized resistance exercise (RE) prescriptions is emphasized, and research on sex/gender differences needs to be conducted. Our review focused on the effects of resistance exercise on muscle strength, muscle hypertrophy, and muscle function in older adults in relation to sex differences. In this review, we aimed to analyze sex differences in the effect of RE on older adults with sarcopenia and provide meaningful information for future research on exercise programs for individuals with sarcopenia.