头孢曲松治疗儿童血压的评估:一项病例对照研究

Q3 Pharmacology, Toxicology and Pharmaceutics

Jordan Journal of Pharmaceutical Sciences Pub Date : 2023-09-23 DOI:10.35516/jjps.v16i3.1608

Mahdi Esmaeili, Roham Sarmadian, Gholamali Fatahibayat, Parsa Yousefichaijan, Danial Habibi

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引用次数: 0

摘要

背景:儿童高血压可在青春期和成年期发展为高血压及其后果。儿童高血压通常继发于其他原因，包括肾脏疾病。肾结石是继发性高血压的病因之一。医院广泛使用头孢菌素，特别是头孢曲松，可导致肾结石。因此，本研究的目的是评估头孢曲松治疗与儿童血压升高之间的关系。方法:采用2018 - 2019年18个月的病例对照研究。在这项研究中，测量了在Arak Amir Kabir医院住院并接受头孢曲松治疗至少48小时的111名3-13岁儿童的血压。作为对照组，111名未接受头孢曲松治疗的儿童测量了血压。然后比较两组儿童的血压水平和百分位数。结果:病例组和对照组的平均年龄分别为5.1±1.61岁和6.04±2.4岁，平均身高分别为109.17±10.71和114.86±12.95 cm。病例组收缩压平均值(65.59±18.17)略高于对照组(65.28±14.51)(P=0.112)，舒张压平均值(58.89±18.88)略高于对照组(54.85±19.28)(P=0.317)。舒张压差异大于收缩压差异。然而，这些检测到的差异是轻微的，没有统计学意义。结论:本研究显示，在服用头孢曲松至少48小时的3岁以上儿童中，血压水平与头孢曲松治疗之间没有关联。然而，建议进行更多的研究，重点关注药物在较高剂量和服药后较长时间内的效果。

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Evaluation of Blood Pressure in Children Treated with Ceftriaxone: A Case-Control Study

Background: In children, high blood pressure can develop into hypertension and its consequences during puberty and adulthood. High blood pressure in children is often secondary to other causes, including renal diseases. Nephrolithiasis is one of the causes of secondary hypertension. The extensive use of cephalosporins in hospitals, particularly ceftriaxone, can result in nephrolithiasis. Therefore, the purpose of this study was to assess the relationship between ceftriaxone treatment and elevated blood pressure in children. Method: The research was conducted as a case-control study over an 18-month period from 2018 to 2019. In this study, blood pressure was measured in 111 children aged 3-13 years who were hospitalized at Amir Kabir Hospital in Arak and received ceftriaxone for at least 48 hours. As a control group, 111 children who did not receive ceftriaxone had their blood pressure measured. The blood pressure levels and percentiles of children in the two groups were then compared. Result: In the case and control groups, the mean age was 5.1±1.61 and 6.04±2.4 years, and the mean height was 109.17±10.71 and 114.86±12.95 cm, respectively. A slightly higher mean systolic blood pressure percentile was observed in the case group (65.59±18.17) than in the control group (65.28±14.51) (P=0.112), and the mean diastolic blood pressure percentile was also slightly higher in the case group (58.89±18.88) than in the control group (54.85±19.28) (P=0.317). The difference in diastolic blood pressure was greater than in systolic blood pressure. However, these detected differences were slight and not statistically significant. Conclusion: This study showed no association between blood pressure levels and ceftriaxone treatment in children older than three years who received the medicine for at least 48 hours. However, additional research is suggested, focusing on the effects of the medicine at higher doses and over a longer period of time following administration.

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来源期刊

Jordan Journal of Pharmaceutical Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

1.70

自引率

0.00%

发文量

期刊介绍： The Jordan Journal of Pharmaceutical Sciences (JJPS) is a scientific, bi-annual, peer-reviewed publication that will focus on current topics of interest to the pharmaceutical community at large. Although the JJPS is intended to be of interest to pharmaceutical scientists, other healthy workers, and manufacturing processors will also find it most interesting and informative. Papers will cover basic pharmaceutical and applied research, scientific commentaries, as well as views, reviews. Topics on products will include manufacturing process, quality control, pharmaceutical engineering, pharmaceutical technology, and philosophies on all aspects of pharmaceutical sciences. The editorial advisory board would like to place an emphasis on new and innovative methods, technologies, and techniques for the pharmaceutical industry. The reader will find a broad range of important topics in this first issue.