A systematic review and meta-analysis of Surpass flow diverter for the treatment of intracranial aneurysms

Abstract Objective Systematically review and analyze the published literature on the safety and efficacy of Surpass flow diverter in terms of mortality, functional outcome, complication rate, and aneurysm occlusion rate. Methods The literature was searched in PubMed, MEDLINE, Embase, and Scopus using the terms Surpass for the treatment of Intracranial aneurysms, Intracranial aneurysms, Complication with no constraints applied. Two review authors independently conducted the study selection. Two review authors independently extracted study data. Data were pooled using a random effect model, results were abstracted as odds ratios and 95% CI, and heterogeneity was reported as I 2 . Results Five studies were included, which involved retrospectively and prospectively collected data on 464 patients. The use of Surpass flow diverter was associated with a rate of occlusion of 73.4% (95% confidence interval [CI] 62.48–83.077%). Low rate of thromboembolic complication was 6.6% (95% CI 3.0–10.1%), the rate of hemorrhagic complication was 2.9% (95% CI 1.6–4.6%), and low vasospasm rate was 4.38% (95% confidence interval [CI] 1.8–7.7%). The mortality rate was 4.6% (95% CI 1.4–1.4%). An overall of good outcome was 86.6% (95% CI 75.9–94.5%), and poor outcome was 7.8% (95% CI 5.0–11.2%). Conclusions Based on the studies available in the literature, Surpass flow diverter offers high aneurysm occlusion rates with adequate safety and low rate of complications.