电化学传感器和免疫传感器在检测癌症生物标志物方面的优势比较研究

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-10-31 DOI:10.55730/1300-0527.3587

GÖKSU ÖZÇELİKAY, AHMET ÇETİNKAYA, SARİYE İREM KAYA, SİBEL AYŞIL ÖZKAN

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引用次数: 0

摘要

癌症在全球变得越来越普遍，死亡率很高。尽管对诊断和治疗方法进行了大量研究，技术发展带来了好处，以及新开发的传感器设备，但癌症仍然是全球死亡的主要原因之一。使用强大的非侵入性工具进行早期检测可能是未来预后和治疗随访的重点。因此，电化学生物传感器具有灵敏度高、选择性好、成本低、分析时间短、操作简单等优点，是检测癌症生物标志物(如甲胎蛋白、细胞色素c、前列腺特异性抗原、肌红蛋白、癌胚抗原、甲胎蛋白、癌抗原、表皮生长因子受体、血管内皮生长因子、循环肿瘤细胞、乳腺癌抗原1/2)的有力选择。此外，电化学生物传感器更适合于点护理应用，因为它们易于批量生产和小型化。本文综述了不同的电化学测量技术，生物受体表面，信号的产生和放大，以及电化学修饰传感器的集成。详细介绍了基于电化学生物传感器的癌症生物标志物。此外，基于mip的传感器和免疫传感器的研究也得到了广泛的讨论。将电化学生物传感器与癌症生物标志物相结合是一个新的研究方向。最后，我们概述了目前使用电化学生物传感器测量和分析癌症生物标志物的进展，并详细介绍了当前的挑战和未来的展望

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Comparative study of electrochemical-based sensors and immunosensors in terms of advantageous features for detection of cancer biomarkers

Cancer, becoming increasingly common globally, has a high mortality rate. Despite the much research on diagnosis and treatment methods, the benefits of technological developments, and newly developed sensor devices, cancer is still one of the leading causes of death worldwide. Early detection using powerful and noninvasive tools could be a future focus for prognosis and treatment follow-up. Therefore, electrochemical biosensors can be a strong choice for the detection of cancer biomarkers (such as alpha-fetoprotein, cytochrome c, prostate-specific antigen, myoglobin, carcinoembryonic antigen, alpha-fetoprotein, a cancer antigen, epidermal growth factor receptor, vascular endothelial growth factor, circulating tumor cell, and breast cancer antigen 1/2) due to their advantages such as high sensitivity, excellent selectivity, low cost, short analysis time, and simplicity. Furthermore, electrochemical biosensors are better suited for point-of-care applications due to their mass production and miniaturization ease. This review provides an overview of different electrochemical measurement techniques, bioreceptor surfaces, signal production and amplification, and the integration of electrochemical-modified sensors. Cancer biomarkers based on electrochemical biosensors were given in detail. In addition, studies with MIP-based sensors and immunosensors have been extensively discussed. Integrating electrochemical biosensors with cancer biomarkers was also emphasized as a new research trend. Finally, we provide an overview of current advances in measuring and analyzing cancer biomarkers using electrochemical biosensors and detail current challenges and future perspectives

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.