利用胶束催化通过Suzuki-Miyaura交叉偶联合成4 -氯- 6 -(6 -甲氧基吡啶- 3 -基)嘧啶

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-10-18 DOI:10.1002/hlca.202300143

Nicholas A. Isley, Fabrice Gallou

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引用次数: 0

摘要

摘要:本文报道了一种可扩展的、环境友好的、使用维生素E衍生表面活性剂TPGS‐750‐M在水中进行Suzuki-Miyaura交叉偶联的方案。该协议是在胶束催化下进行此类转化的最简单和最标准的协议，在过去十年中已在我们自己的研究和开发组合中得到充分利用。合成过程的影响通过绿色过程质量强度和总碳释放得到加强。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Kilogram-Scale Synthesis of 4-Chloro-6-(6-methoxypyridin- 3-yl)pyrimidine through a Suzuki–Miyaura Cross-Coupling Using Micellar Catalysis

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Kilogram-Scale Synthesis of 4-Chloro-6-(6-methoxypyridin- 3-yl)pyrimidine through a Suzuki–Miyaura Cross-Coupling Using Micellar Catalysis

A scalable and environmentally benign protocol for a Suzuki–Miyaura cross-coupling in water using vitamin E derived surfactant TPGS-750-M is reported. The protocol is the most simple and standard for such transformations under micellar catalysis that has been amply utilized within our own research and development portfolio over the last decade. The impact of the synthetic procedure is reenforced by green Process Mass Intensity and Total Carbon Release metrics.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.