COPPER COORDINATION COMPOUNDS WITH THIOSEMICARBAZONES: IN VITRO ASSESSMENT OF THEIR POTENTIAL IN INHIBITING GLIOMA VIABILITY AND PROLIFERATION

cellulaire de gliome C6, viabilité, prolifération, test de rézazurine. (ref CCL-107). Rat C6 glioma cells were grown in 200 mL cell culture flasks and maintained in a 3.5% CO2 incubator (ico50 Memmert GmbH Germany) at 37°C. The compounds were administered in doses of 1 μ M and 10 μ M. The viability was evaluated by MTT test and proliferation by resazurin one. Results. The study results show that the compounds have selective action on in vitro viability and proliferation of C6 glioma cells that depends on the chemical structure and concentration. Conclusions. Phenyl derivatives showed a more promising action on C6 glioma cells viability and proliferation compared with benzothiazole and alyl thiosemicarbazones. Also, a lower concentration (1 μ M) was more efficient than the higher one (10 μ M).