泰米尔纳德邦海岸几种海藻抗病毒效果的筛选

Saranya N, Sri Abarajitha R, Anandhasayanan T, Jaivignesh D, Mugunthan B, Yuvaraj Dinakarkumar, Kirubanandan Shanmugam
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摘要

近年来,以海洋多糖为代表的海洋天然次生代谢物的抗病毒活性研究受到了广泛的关注。研究表明,海洋多糖及其衍生物对强效病毒具有抗病毒作用。农业、生物、食品和制药行业都广泛使用从藻类中获得的产品。在藻类中发现的最著名的化学成分是多糖,由于其多种生物活性,多糖一直是各种研究的主题。从藻类中提取的多糖由于其令人着迷的抗病毒潜力,最近已上升到制药研究的顶端。目前,COVID-19可以通过接种疫苗来预防,但褐藻马尾藻含有几种生物活性化合物,具有以下特性,可能是更好的选择。双歧藻是一种富含硫酸多糖的海藻,其次生代谢产物具有抗病毒作用和抑制病毒增殖的能力。岩藻聚糖是一种在各种褐藻中发现的长链硫酸酸化多糖,具有有效的抗病毒作用。此外,来自绿藻(如紫藻)和红藻(如卡拉胶)的硫酸酸化多糖,以及来自红藻的凝集素(如格里菲斯素)具有抗冠状病毒和其他病毒的抗病毒治疗剂。本研究的重点是筛选海藻中可能的抗病毒化合物,以治疗病毒感染,特别是COVID-19。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Screening of Antiviral Efficacy of Few Seaweeds of Tamil Nadu Coast
Lately there has been a lot of interest worldwide in studies on the antiviral activities of marine natural secondary metabolites, notably marine polysaccharides. It has been established that polysaccharides made from marine sources and their derivatives have antiviral effects against potent viruses. Agricultural, biological, food, and pharmaceutical industries all make extensive use of goods obtained from algae. The most well-known chemical components found in algae are polysaccharides, which have been the subject of a variety of studies because of their varied bioactivities. Polysaccharides made from algae have recently risen to the top of pharmaceutical research due to their fascinating antiviral potential. Currently, COVID-19 can be prevented with vaccination, but the brown alga Sargassum wightii has several bioactive compounds that have the following qualities and may be a better option. S. wightii is one of the marine algae species that is rich in sulfated polysaccharides, the secondary metabolites which have antiviral action and the capacity to prevent viral proliferation. Fucoidan, a long-chain sulfated polysaccharide found in various brown algae, has potent antiviral effects. Additionally, sulfated polysaccharides from green algae (such as ulvans) and red algae (such as carrageenan), and lectins from red algae (such as griffithsin) have antiviral therapeutic agents against coronaviruses and other viruses. This research focuses on screening seaweeds for possible antiviral compounds to treat viral infections notably COVID-19.
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