精神压力有助于动脉粥样硬化性心脑疾病的发病机制:一个小回顾

IF 1 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS
Yong-Jian Geng
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引用次数: 0

摘要

动脉粥样硬化性血管疾病有两种危及生命的并发症,即心肌梗死和脑梗死。这两种病理状况的发展涉及遗传、表观遗传和环境因素之间的相互作用。精神压力是导致动脉粥样硬化性心脑疾病发病的一个独立因素。精神压力的增加与血管僵硬、炎症、动脉粥样硬化和高血压的加剧有关。应激对神经内分泌的影响包括肾素-血管紧张素系统及其活性肽的参与,特别是血管紧张素II (Ang II)在应激相关疾病中的作用。以昼夜节律的方式,Ang II及其两种受体亚型存在于应激反应性脑下丘脑-肾上腺-垂体轴中。精神压力会导致心碎综合症或应激性心肌病。应激恢复是调节应激相关心血管功能障碍易感性和不良事件发生的重要因素。预防和治疗方法在多个方面发展,旨在减轻压力相关的血管反应和动脉粥样硬化性血管疾病的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mental stress contributes to the pathogenesis of atherosclerotic heart and brain diseases: A mini-review
Atherosclerotic vascular diseases have two life-threatening complications, namely myocardial and cerebral infarcts. The development of the two pathological conditions involves interplays between genetic, epigenetic, and environmental factors. Mental stress is an independent factor that contributes to the pathogenesis of atherosclerotic heart and brain diseases. Increased mental stress is linked to heightened vascular stiffness, inflammation, atherosclerosis, and hypertension. Neuroendocrinological impacts of stress include the involvement of the renin-angiotensin system and its active peptides, particularly angiotensin II (Ang II), in stress-related disorders. In a circadian manner, Ang II and its two subtypes of receptors exist in the stress-responsive brain hypothalamus–adrenal–pituitary axis. Mental stress can cause broken heart syndrome or stress cardiomyopathy. Stress resilience is an important factor that regulates the susceptibility to stress-associated cardiovascular dysfunction and the development of adverse events. Preventive and therapeutic approaches are developed on multiple fronts aimed at mitigating the stress-associated vascular responses and development of atherosclerotic vascular disorders.
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来源期刊
CiteScore
1.10
自引率
0.00%
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10
审稿时长
19 weeks
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