主侧含有乙二醇链的β-环糊精：作为 17-β-estradiol 增溶剂的制备和评估以及 17-β-estradiol 包合物的核磁共振结构分析

IF 2.3 4区化学 Q2 Agricultural and Biological Sciences

Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2023-10-31 DOI:10.1007/s10847-023-01206-0

Yoshiki Oda, Junki Nakagawa, Kaname Kasturaya, Takashi Yamanoi

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引用次数: 0

摘要

本研究设计并制备了两种新型含乙二醇链的β-环糊精(1和2)，以开发高水溶性环糊精。它们具有良好的水溶性，可以成功地将17-β-雌二醇溶解在水中，被认为是一种难溶性药物模型。此外，对17-β-雌二醇和1在d20 - h2o中的混合样品进行核磁共振结构分析，发现在1的空腔内存在两种不同类型的17-β-雌二醇分子取向的包合物。图形抽象

本文章由计算机程序翻译，如有差异，请以英文原文为准。

β-Cyclodextrins bearing ethylene glycol chains at their primary side: their preparations and evaluation as solubilizing agents for 17-β-estradiol and nuclear magnetic resonance structural analysis of a 17-β-estradiol inclusion complex

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In this study, we designed and prepared two new β-cyclodextrins (1 and 2) bearing ethylene glycol chains to develop highly water-soluble cyclodextrins. They had excellent water solubility and could successfully dissolve 17-β-estradiol in water, which was considered a poorly soluble drug model. Additionally, the nuclear magnetic resonance structural analysis of a mixed sample of 17-β-estradiol and 1 in D₂O–H₂O suggested two different types of inclusion complexes with different 17-β-estradiol molecule orientations inside the cavity of 1.

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来源期刊

Journal of Inclusion Phenomena and Macrocyclic Chemistry 化学-化学综合

CiteScore

3.30

自引率

8.70%

发文量

审稿时长

3-8 weeks

期刊介绍： The Journal of Inclusion Phenomena and Macrocyclic Chemistry is the premier interdisciplinary publication reporting on original research into all aspects of host-guest systems. Examples of specific areas of interest are: the preparation and characterization of new hosts and new host-guest systems, especially those involving macrocyclic ligands; crystallographic, spectroscopic, thermodynamic and theoretical studies; applications in chromatography and inclusion polymerization; enzyme modelling; molecular recognition and catalysis by inclusion compounds; intercalates in biological and non-biological systems, cyclodextrin complexes and their applications in the agriculture, flavoring, food and pharmaceutical industries; synthesis, characterization and applications of zeolites. The journal publishes primarily reports of original research and preliminary communications, provided the latter represent a significant advance in the understanding of inclusion science. Critical reviews dealing with recent advances in the field are a periodic feature of the journal.