2018年呼吸道合胞病毒细支气管炎:一项对约翰内斯堡两家三级医院住院儿童的描述性研究

IF 0.2 Q4 PEDIATRICS
TS Cleak, DE Ballot, NM Moshesh, L Chirwa, T Thomas, DA White
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引用次数: 0

摘要

背景。呼吸道合胞病毒(RSV)是全世界儿童严重毛细支气管炎最常见的病因。目的:描述毛细支气管炎住院儿童的临床特点和预后,并将rsv毛细支气管炎与其他病毒性毛细支气管炎患儿进行比较。回顾性研究了2018年2月1日至8月31日期间在夏洛特麦克塞克约翰内斯堡学术医院(CMJAH)和纳尔逊曼德拉儿童医院(NMCH)接受病毒筛查的毛细支气管炎患儿,并对rsv阳性和阴性患儿进行了比较。这些儿童被国家卫生实验室鉴定为接受了呼吸道病毒多重分子分析,并对医院图表进行了回顾性回顾。本研究共比较了131例来自CMJAH和NMCH的毛细支气管炎患儿,其中58例来自CMJAH, 73例来自NMCH。在样本组中,65例(49.6%)患儿有RSV, 66例(50.4%)患儿无RSV。RSV患儿中,55例(42%)为单纯RSV患儿,10例(7.6%)为RSV合并其他呼吸道病毒患儿。鼻病毒是该队列儿童中检测到的第二常见病毒(n=17, 12.9%),其次是腺病毒(n=12, 9.2%)和冠状病毒(n=9, 6.9%)。RSV毛细支气管炎患儿需要住院治疗的一个具有统计学意义的危险因素是年龄小于6个月(p<0.001)。毛细支气管炎是儿童常见病。呼吸道合胞病毒是6个月以下住院婴儿严重毛细支气管炎的最常见原因。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
RSV bronchiolitis in 2018: A descriptive study of children admitted to two Johannesburg tertiary hospitals
Background. Respiratory syncytial virus (RSV) is the most common cause of severe bronchiolitis in children worldwide.Objectives. To describe clinical characteristics and outcomes of children hospitalised with bronchiolitis and to compare those with RSVbronchiolitis with children with other viral causes of bronchiolitis.Methods. A retrospective study of children admitted with virally screened bronchiolitis to Charlotte Maxeke Johannesburg AcademicHospital (CMJAH) and Nelson Mandela Children’s Hospital (NMCH) from 1 February to 31 August 2018 was conducted, where RSVpositive and -negative children were compared. These children were identified by the National Health Laboratory Service as havingundergone respiratory viral multiplex molecular assay analysis and hospital charts were retrospectively reviewed.Results. A total of 131 children admitted with bronchiolitis from CMJAH and NMCH were compared in this study, 58 from CMJAHand 73 from NMCH. In the sample group, 65 (49.6%) children had RSV in comparison with 66 (50.4%) children without RSV. Childrenwith RSV comprised 55 (42%) children with RSV only and 10 (7.6%) children with RSV in combination with another respiratory virus.Rhinovirus was the second most common virus detected in this cohort of children (n=17, 12.9%) followed by adenovirus (n=12, 9.2%)and coronavirus (n=9, 6.9%). A statistically significant risk factor noted in children requiring hospitalisation for RSV bronchiolitis wasage less than six months (p<0.001).Conclusions. Bronchiolitis is a common disease in children. Respiratory syncytial virus is the most common cause of severe bronchiolitis in hospitalised infants less than six months of age.
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来源期刊
CiteScore
0.60
自引率
0.00%
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21
审稿时长
12 weeks
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