特纳综合征嵌合型多囊卵巢患者的卵母细胞冷冻技术

Anna Sienko B.A. , Alka Prakash M.D. , Jane MacDougall M.D.
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引用次数: 0

摘要

目的报告一例特纳综合征(TS)嵌合和多囊卵巢综合征(PCOS)患者,该患者成功接受了卵巢刺激、卵母细胞提取和冷冻保存。干预措施:控制性卵巢刺激、卵母细胞取回和冷冻保存。结果 我们报告了一例有趣的 TS 嵌合型 45,X [24%]/46,XX [76%] 和父方遗传的 t(2:6)平衡互易位,根据少经和超声多囊卵巢形态(左侧和右侧卵巢前卵泡数分别为 17 和 20)诊断为多囊卵巢综合征,接受了 2 个周期的卵巢刺激、卵母细胞取回和冷冻保存,获得了 19 个冷冻保存的卵母细胞。结论:我们的病例强调了早期咨询镶嵌型 TS 患者生育选择的重要性,以及在此过程中仔细监测卵巢储备功能的必要性,可通过测量抗苗勒氏管激素或前卵泡计数来监测卵巢储备功能。该病例还强调了患有马赛克TS的妇女受多囊卵巢综合症影响的可能性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Oocyte cryopreservation in mosaic Turner syndrome with polycystic ovaries

Objective

To report a case of a patient with Turner syndrome (TS) mosaicism and polycystic ovarian syndrome (PCOS), who underwent successful ovarian stimulation, oocyte retrieval, and cryopreservation.

Design

Case report.

Subject(s)

A female patient with mosaic TS (45,X [24%]/46,XX [76%]) and a paternally inherited balanced reciprocal translocation t(2:6) diagnosed with PCOS.

Intervention(s)

Controlled ovarian stimulation, oocyte retrieval, and cryopreservation.

Main outcome measure(s)

Successful oocyte retrieval and cryopreservation.

Result(s)

We report an interesting case of a patient with TS mosaicism 45,X [24%]/46,XX [76%] and a paternally inherited t(2:6) balanced reciprocal translocation, who was diagnosed with PCOS on the basis of oligomenorrhea and ultrasound polycystic ovary morphology (antral follicle count of 17 and >20, left and right ovaries, respectively), underwent 2 cycles of ovarian stimulation, oocyte retrieval, and cryopreservation, resulting in 19 cryopreserved oocytes.

Conclusion(s)

Our case highlights the importance of early counseling regarding fertility options in patients with mosaic TS and the need for careful monitoring of ovarian reserve during this process, which could be done by measuring the anti-müllerian hormone or antral follicle count. It also underscores the possibility of women with mosaic TS being affected by PCOS.

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来源期刊
FS Reports
FS Reports Medicine-Embryology
CiteScore
3.50
自引率
0.00%
发文量
78
审稿时长
60 days
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