在实验室试剂中加入麦克尔斯溶液对神经病理学家有好处吗?

IF 0.8 4区 医学 Q4 TROPICAL MEDICINE
Biomedica Pub Date : 2023-06-25 DOI:10.24911/biomedica/5-339
Tuaha Amjad, Muhammad Hassan Malik, Ghulam Rasool, Shameen Shoaib
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引用次数: 1

摘要

术中冷冻切片会诊的重要性再怎么强调也不为过。冷冻切片诊断的总体准确率在92% ~ 97.98%之间;然而,在脑组织中,考虑到冰晶形成、挤压和过度拉伸导致的组织形态学受损,诊断的准确性是有争议的。另一方面,由于报道的解释问题,依赖于冷冻脑切片的免疫组织化学更具挑战性。因此,保留脑组织的组织形态学和优化分析前变量对于患者的准确诊断至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Will Adding Michel&rsquo;s Solution to the Laboratory Reagents do Any Good for the Neuropathologists?

The importance of intraoperative consultation through frozen sections can hardly be over-emphasized. The overall accuracy of frozen section diagnosis falls within the range of 92% to 97.98%; however, in brain tissues, the diagnostic accuracy is debatable, considering the artifacts due to ice crystal formation, crushing, and overstretching resulting in impaired histomorphology. On the other hand, reliance on immunohistochemistry on a frozen brain section is even more challenging because of reported interpretational problems. Hence, preserving the histomorphology of brain tissues and optimizing preanalytical variables is crucial for the accurate diagnosis of the patients.

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来源期刊
Biomedica
Biomedica 医学-热带医学
CiteScore
1.60
自引率
0.00%
发文量
76
审稿时长
>12 weeks
期刊介绍: Biomédica is the quarterly journal of the Instituto Nacional de Salud of Colombia [Colombia’s National Health Institute]. Its purpose is to publish the results of original research that contributes meaningfully to knowledge in health and biomedical sciences.
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