Tuaha Amjad, Muhammad Hassan Malik, Ghulam Rasool, Shameen Shoaib
{"title":"在实验室试剂中加入麦克尔斯溶液对神经病理学家有好处吗?","authors":"Tuaha Amjad, Muhammad Hassan Malik, Ghulam Rasool, Shameen Shoaib","doi":"10.24911/biomedica/5-339","DOIUrl":null,"url":null,"abstract":"<p>The importance of intraoperative consultation through frozen sections can hardly be over-emphasized. The overall accuracy of frozen section diagnosis falls within the range of 92% to 97.98%; however, in brain tissues, the diagnostic accuracy is debatable, considering the artifacts due to ice crystal formation, crushing, and overstretching resulting in impaired histomorphology. On the other hand, reliance on immunohistochemistry on a frozen brain section is even more challenging because of reported interpretational problems. Hence, preserving the histomorphology of brain tissues and optimizing preanalytical variables is crucial for the accurate diagnosis of the patients.</p>","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":"98 1","pages":"0"},"PeriodicalIF":0.8000,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Will Adding Michel&rsquo;s Solution to the Laboratory Reagents do Any Good for the Neuropathologists?\",\"authors\":\"Tuaha Amjad, Muhammad Hassan Malik, Ghulam Rasool, Shameen Shoaib\",\"doi\":\"10.24911/biomedica/5-339\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The importance of intraoperative consultation through frozen sections can hardly be over-emphasized. The overall accuracy of frozen section diagnosis falls within the range of 92% to 97.98%; however, in brain tissues, the diagnostic accuracy is debatable, considering the artifacts due to ice crystal formation, crushing, and overstretching resulting in impaired histomorphology. On the other hand, reliance on immunohistochemistry on a frozen brain section is even more challenging because of reported interpretational problems. Hence, preserving the histomorphology of brain tissues and optimizing preanalytical variables is crucial for the accurate diagnosis of the patients.</p>\",\"PeriodicalId\":9186,\"journal\":{\"name\":\"Biomedica\",\"volume\":\"98 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2023-06-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomedica\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.24911/biomedica/5-339\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"TROPICAL MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedica","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.24911/biomedica/5-339","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"TROPICAL MEDICINE","Score":null,"Total":0}
Will Adding Michel’s Solution to the Laboratory Reagents do Any Good for the Neuropathologists?
The importance of intraoperative consultation through frozen sections can hardly be over-emphasized. The overall accuracy of frozen section diagnosis falls within the range of 92% to 97.98%; however, in brain tissues, the diagnostic accuracy is debatable, considering the artifacts due to ice crystal formation, crushing, and overstretching resulting in impaired histomorphology. On the other hand, reliance on immunohistochemistry on a frozen brain section is even more challenging because of reported interpretational problems. Hence, preserving the histomorphology of brain tissues and optimizing preanalytical variables is crucial for the accurate diagnosis of the patients.
期刊介绍:
Biomédica is the quarterly journal of the Instituto Nacional de Salud of Colombia [Colombias National Health Institute]. Its purpose is to publish the results of original research that contributes meaningfully to knowledge in health and biomedical sciences.