发现一种新的杀螨剂，无虫螨

IF 1.5 4区农林科学 Q2 ENTOMOLOGY

Journal of Pesticide Science Pub Date : 2023-01-01 DOI:10.1584/jpestics.d23-028

Isami Hamamoto, Masahiro Kawaguchi, Takehiko Nakamura, Makio Yano, Keiji Koizumi, Jun Takahashi

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引用次数: 0

摘要

Acynonapyr是日本汽水公司发现的一种新型杀螨剂，其独特的核心结构为n -吡啶氧基氮杂二环。对叶螨属和全爪螨属的螨类均有较强的杀灭作用，且在各个生命阶段均有良好的杀灭效果。本研究早期以(杂)芳基(氧)基取代的环胺为靶分子，进行了多种合成，发现4-[4-(三氟甲基)苯氧基]-1-[5-(三氟甲基)-2-吡啶]哌啶具有较弱的杀螨活性。该杀螨活性胡椒碱作为第一个先导化合物进行结构优化，从而发现了刺虫精。在这篇报告中，我们的研究过程导致了acynonapyr的发现。

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Discovery of a novel acaricide, acynonapyr

Acynonapyr, discovered by Nippon Soda Co., Ltd., is a novel acaricide with N-pyridyloxy azabicycle as a unique core structure. Acynonapyr exhibits high activity against the spider mite species in the genera Tetranychus and Panonychus, with good efficacy at all life stages. Early in this research, cyclic amines substituted with (hetero)aryl(oxy) moieties were designed as target molecules and diversely synthesized, and 4-[4-(trifluoromethyl)phenoxy]-1-[5-(trifluoromethyl)-2-pyridyl]piperidine was found to show weak acaricidal activity. The structural optimization of this acaricidal active piperidine as the first lead compound led to the discovery of acynonapyr. In this report, our research process that led to the discovery of acynonapyr is described.

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来源期刊

Journal of Pesticide Science 农林科学-昆虫学

CiteScore

4.30

自引率

4.20%

发文量

审稿时长

18-36 weeks

期刊介绍： The Journal of Pesticide Science publishes the results of original research regarding the chemistry and biochemistry of pesticides including bio-based materials. It also covers their metabolism, toxicology, environmental fate and formulation.