Minh Hoang Le, Huyen Sanh Sam, Duy Toan Pham, Ngoc Chi Lan Nguyen, Ngoc Diem Le, Tran Nhat Phong Dao
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引用次数: 0
摘要
本研究旨在评估越南传统药物ngu - vi - tieuu - khat (NVTK)汤对2型糖尿病大鼠模型的降糖作用。采用浸渍法制备NVTK煎剂，通过测定血糖水平、胰岛素抵抗指标和胰腺质量来检测其降血糖作用。结果显示，NVTK汤改善糖尿病症状，提高胰岛素水平，降低胰岛素抵抗，恢复胰腺质量，降低总胆固醇(TC)、甘油三酯(TG)和低密度脂蛋白胆固醇(LDL-C)，升高高密度脂蛋白胆固醇(HDL-C)。NVTK的降糖作用与剂量为10mg /kg的格列齐特相当。综上所述，NVTK汤具有降糖作用，可作为治疗人类2型糖尿病的潜在传统药物。
Ngu-Vi-Tieu-Khat decoction, a Vietnamese traditional medicine, possesses hypoglycemic and hypolipidemic effects on streptozotocin-induced type-2 diabetic rat model
This study aims to assess the hypoglycemic effects of Ngu-Vi-Tieu-Khat (NVTK) decoction, a traditional Vietnamese medicine, in a rat model of type-2 diabetes. The NVTK decoction was prepared using the maceration method and tested for its hypoglycemic effects by measuring blood glucose levels, insulin resistance indicators, and pancreatic mass. The results showed that NVTK decoction improved diabetes symptoms, increased insulin levels, reduced insulin resistance, restored pancreatic mass, and decreased total cholesterol (TC), triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C) while increasing high-density lipoprotein cholesterol (HDL-C). The hypoglycemic effects of NVTK were comparable to those of gliclazide at a dose of 10 mg/kg. In conclusion, NVTK decoction possesses hypoglycemic properties and could be explored as a potential traditional medicine for treating type-2 diabetes in humans.
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