Synthesis of water-soluble analogs-polymers of poly-N-vinylpyrolidone grafted with zinc phthalocyanine

The paper describes the synthesis of polymer analogues of N-vinylpyrrolidone with acryloyl chloride functionalized with zinc phthalocyanine, by using the Friedel-Crafts method. The grafting of zinc phthalocyanine to Nvinylpyrrolidone copolymers was carried out at low temperatures (3-5 ⁰C), using the anhydrous AlCl3 catalyst. The purification of the new polymers was carried out by sedimentation in water. The chemical structure of polymer analogues were performed by IR, UV/Vis spectroscopy. The bactericidal properties of the synthesized polymer analogs were studied. The antibacterial activity of grafted copolymers with zinc phthalocyanine was performed „in vitro”, with a series of bactericidal cultures such as S. Aureus, E. Coli, Ps. Aeruginosa and others. It has been shown that the obtained polymer analogs possess relatively high bactericidal activity against some cultures such as Ps. Aeruginosa, Pr. Vulgaris to the action of furacilin or chlorhexidines, used as controls.