香豆素-3-羧酰胺衍生物的合成及抗菌活性研究

IF 0.4 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Revue Roumaine De Chimie Pub Date : 2023-01-17 DOI:10.33224/rrch.2023.68.1-2.08

Hülya ÇELIK-ONAR, Gökçe BAYRAMOĞLU, Emel MATARACI-KARA

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引用次数: 0

摘要

本研究以香豆素-3-羧酸氯和不同的胺为原料合成了9个香豆素-3-羧胺衍生物3a-3i。其中两个，3c和3i，是原始的。采用柱层析法对新物质进行了纯化，并用波谱(1H NMR、13C NMR、IR)和元素分析对其结构进行了鉴定。研究了香豆素-3-羧酰胺衍生物对10种不同的ATTC菌株的抗菌作用。化合物3f在抗菌和抗真菌活性方面是最有效的化合物。

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Synthesis and antimicrobially activities of coumarin-3-carboxamide derivatives

In this study nine coumarin-3-carboxamide derivatives 3a-3i were synthesized with coumarin-3-carboxylic acid chloride and different amines. Two of them, 3c and 3i, are original. The novel substances were purified by column chromatography, and their structures were identified by spectroscopic methods (1H NMR, 13C NMR, IR) and elemental analysis. Coumarin-3-carboxamide derivatives were evaluated antimicrobially against ten different ATTC isolates. The compound 3f was found to be the most effective compound in terms of antibacterial and antifungal activities.

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来源期刊

Revue Roumaine De Chimie 化学-化学综合

CiteScore

0.80

自引率

20.00%

发文量

审稿时长

>12 weeks

期刊介绍： The journal Revue Roumaine de Chimie (Roumanian Journal of Chemistry) was founded in 1956 under the name Revue de Chimie. Acad. R. P. R. from 1964, the title was modified in Revue Roumaine de Chimie (preserving the numbering of the volumes started in 1956). In 1997, the English translation of the title – Roumanian Journal of Chemistry – was also included on each issue.