中性粒细胞绝对计数和单核细胞绝对计数作为急性淋巴细胞白血病患者造血恢复预测因子的比较分析

IF 3.4 2区医学 Q1 PATHOLOGY

Journal of Pathology Clinical Research Pub Date : 2023-01-01 DOI:10.23880/cprj-16000159

Yesmin MS

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引用次数: 0

摘要

目的:探讨急性淋巴细胞白血病(acute lymphoblastic leukemia, ALL)患者造血恢复过程中中性粒细胞绝对计数与单核细胞绝对计数的比较。方法:对50例年龄在8个月~ 15岁的急性淋巴细胞白血病患者进行前瞻性研究。结果:在初始治疗阶段(诱导缓解期)，在绝对单核细胞计数(AMC)恢复之前，绝对中性粒细胞计数(ANC)有规律地增加趋势。在所有参数中，ANC比AMC(≥0.1 x 109 /l)恢复早1天(≥0.5 x 109 /l)。结论:ANC可作为AMC患者造血功能恢复的早期预测指标。这些参数可与临床条件结合使用，以决定白血病患者的早期出院，特别是在发展中国家，因为长期住院可能导致医院获得性感染。

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Comparative Analysis between Absolute Neutrophil Count and Absolute Monocyte Count as a Predictor of Haematopoietic Recovery in Patients with Acute Lymphoblastic Leukaemia

Objectives: This study was aimed to find out the comparison between absolute neutrophil count and absolute monocyte count for haematopoietic recovery in acute lymphoblastic leukaemia (ALL) patients. Methods: In this study, a total of 50 patients of acute lymphoblastic leukaemia, aged between 8 months to 15 years were studied prospectively. Results: In the initial treatment phase (induction of remission phase), regularly increasing trends were seen in absolute neutrophil counts (ANC) prior to recovery of absolute monocyte counts (AMC). Of all the parameters, ANC recovered 1 day (≥0.5 x 109 /l) prior to recovery of AMC above (≥0.1 x 109 /l). Conclusion: ANC can be considered as an early predictor of haematopoietic recovery over AMC. These parameters can be used in conjunction with clinical conditions to decide about early discharge of leukaemia patients especially in developing countries where prolonged stay can result in hospital acquired infections.

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来源期刊

Journal of Pathology Clinical Research Medicine-Pathology and Forensic Medicine

CiteScore

7.40

自引率

2.40%

发文量

审稿时长

20 weeks

期刊介绍： The Journal of Pathology: Clinical Research and The Journal of Pathology serve as translational bridges between basic biomedical science and clinical medicine with particular emphasis on, but not restricted to, tissue based studies. The focus of The Journal of Pathology: Clinical Research is the publication of studies that illuminate the clinical relevance of research in the broad area of the study of disease. Appropriately powered and validated studies with novel diagnostic, prognostic and predictive significance, and biomarker discover and validation, will be welcomed. Studies with a predominantly mechanistic basis will be more appropriate for the companion Journal of Pathology.