大黄对小鼠高脂饮食诱导的非酒精性脂肪肝的保护作用

IF 1.2 4区医学 Q4 CHEMISTRY, MEDICINAL

Letters in Drug Design & Discovery Pub Date : 2023-11-07 DOI:10.2174/0115701808248646231102075104

Mohammad Reza Mahdinezhad, Farshad Mirzavi, Sara Hooshmand, Shirin Taraz Jamshidi, Ahmad Ghorbani, Mohammad Soukhtanloo

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引用次数: 0

摘要

背景:高脂肪饮食(HFD)是导致非酒精性脂肪性肝病(NAFLD)的主要原因之一，由于生活方式的改变，这种疾病正在增加，并且仍然是一个重要的全球健康问题。尽管做出了努力，但这种疾病仍然没有常见的治疗方法。研究表明，大黄根对糖尿病大鼠的肝脏组织有降血脂作用和显著的抗氧化作用。然而，尚未有实验研究证实该草药对hfd诱导的NAFLD的肝保护作用。背景:高脂肪饮食(HFD)是导致非酒精性脂肪性肝病(NAFLD)的主要原因之一，由于生活方式的改变，这种疾病正在增加，并且仍然是一个重要的全球健康问题。尽管做出了努力，但这种疾病仍然没有常见的治疗方法。研究表明，大黄根对糖尿病大鼠的肝脏组织有降血脂作用和显著的抗氧化作用。然而，目前还没有实验研究证明该草药对hfd诱导的NAFLD有肝保护作用。目的:探讨大黄提取物(RTE)对hfd诱导的BALB/c小鼠NAFLD的影响。材料与方法:采用两种模型研究RTE的预防和治疗效果。通过测定血清生化指标、组织病理学、氧化应激指标和qRTPCR，评价RTE对饲喂HFD小鼠脂质代谢紊乱的影响。结果:在预防模型中，与HFD组相比，RTE治疗降低了葡萄糖、甘油三酯和胆固醇水平，改善了肝脏特征标志物、氧化应激和脂质代谢相关基因的表达。结论:本研究结果表明，RTE通过减少氧化应激、脂肪生成和增加游离脂肪酸的β -氧化，对hff诱导的肝损伤具有肝保护作用。

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Hepatoprotective Effects of Rheum turkestanicum Janisch on High-fat Diet-induced Non-alcoholic Fatty Liver Disease in Mice

Background:: Consumption of a high-fat diet (HFD) is one of the main causes of nonalcoholic fatty liver disease (NAFLD), which is increasing due to lifestyle changes and is still an important global health issue. Despite the efforts, there is still no common treatment for this disease. Studies have shown that the root of Rheum turkestanicum Janisch has a hypolipidemic effect and a significant antioxidant effect on liver tissue in diabetic rats. However, no experimental study has been performed on the hepatoprotective effects of this herb on HFD-induced NAFLD have been proven. background: Consumption of a high-fat diet (HFD) is one of the main causes of non-alcoholic fatty liver disease (NAFLD), which is increasing due to lifestyle changes and is still an important global health issue. Despite the efforts, there is still no common treatment for this disease. Studies have shown that the root of Rheum turkestanicum Janisch has a hypolipidemic effect and a significant antioxidant effect on liver tissue in diabetic rats. However, no experimental study has been performed on which the hepatoprotective effects of this herb on HFD-induced NAFLD have been proven. Objective:: This study aimed to evaluate the effect of Rheum turkestanicum Janisch extract (RTE) on HFD-induced NAFLD in BALB/c mice. Materials and Methods:: The study was performed with two models of prevention and therapeutic effect of RTE. Serum biochemical markers, histopathology, oxidative stress indicators, and qRTPCR were measured to evaluate the effects of RTE on lipid metabolism disorders in mice feeding with HFD. Results:: In the prevention model, compared to the HFD group, RTE treatment decreased the levels of glucose, triglyceride, and cholesterol and improved liver profile markers, oxidative stress, and expression of genes involved in lipid metabolism. Conclusion:: The results of this study suggest that RTE has hepatoprotective effects against HFDinduced liver damage by reducing oxidative stress, lipogenesis, and increasing beta-oxidation of free fatty acids.

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来源期刊

Letters in Drug Design & Discovery 医学-医药化学

CiteScore

1.80

自引率

10.00%

发文量

245

审稿时长

3 months

期刊介绍： Aims & Scope Letters in Drug Design & Discovery publishes letters, mini-reviews, highlights and guest edited thematic issues in all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis is on publishing quality papers very rapidly by taking full advantage of latest Internet technology for both submission and review of manuscripts. The online journal is an essential reading to all pharmaceutical scientists involved in research in drug design and discovery.