1,4 -二氢吡啶衍生物的合成及生物学研究进展

Q4 Earth and Planetary Sciences
Sushma Garapati, Babi Lakkoju, Vandana Vemulapalli, Gowri Sankar Redipalli
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引用次数: 0

摘要

在种类繁多的有机化合物中,杂环化合物是广泛存在于自然界并具有生物活性的有趣化合物。二氢吡啶(DHP)是一种在六元环上以氮为中心的特殊支架。DHP是研究药物化学和药理活性的重要化合物。因此,有机化学家已经做出了相当大的努力,以创造与已知或可能的药效团相关的DHP亚基的新候选药物。Hantzsch是一种被充分研究的DHP和吡啶的合成方法,目前是制备各种DHP衍生物的可靠方法之一。本文重点介绍了近年来国内外对DHP衍生物合成方法的研究进展。本综述的主要目的是讨论合成二氢吡啶衍生物的各种方法,并记录了这些多功能支架的不同药理应用的流行文献。根据其药理活性,在调查中给予了1,4 DHP最高的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Recent synthetic and biological aspects of 1, 4-dihydro pyridine derivatives
Among the large variety of organic compounds, heterocycles are interesting compounds widely occurring in nature, showing biological activities. Dihydropyridine (DHP) is a privileged scaffold having nitrogen in a six-membered cyclic ring as a central moiety. DHP is a significant compound studied in medicinal chemistry and pharmacology activities. Therefore, organic chemists have made considerable efforts to create new drug candidates with DHP subunits associated with a known or possible pharmacophore. The Hantzsch is a well-studied synthesis of DHP and pyridines and is currently one of the reliable approaches for preparing various DHP derivatives along with new approaches. The most recent studies on diverse synthesis methods for DHP derivatives during the preceding years were highlighted in this study. The main objective of this review is to discuss various approaches for synthesizing dihydropyridine derivatives and documented rife literature on the different pharmacological applications of these versatile scaffold. The supreme importance is given to 1, 4 DHP in the survey according to their pharmacological activity.
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来源期刊
CiteScore
0.50
自引率
0.00%
发文量
195
审稿时长
4-8 weeks
期刊介绍: Information not localized
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