Streptomyces sp. VITGV156 (MCC 4965), a quinoline producing Streptomyces

The genus Streptomyces is renowned for its ability to synthesize a wide range of secondary metabolites, encompassing antimicrobial, anticancer, antiviral, antioxidant, immunosuppressant and antimalarial properties. In this study, we focused on Streptomyces sp. VITGV156 to explore its potential in producing quinoline, a secondary metabolite, leveraging the species' extensive biosynthetic gene repertoire. The complete genome of Streptomyces sp. VITGV156 was sequenced using Illumina technology and NextSeq. Genome analysis unveiled 29 Biosynthetic Gene Clusters (BGCs), including 7 PKS (Polyketide Synthases) and 5 terpenes, responsible for secondary metabolite production. The crude extract of VITGV156 was subjected to GC-MS analysis, revealing the presence of 30 distinct compounds, 15 of which exhibited antimicrobial activity. Notably, quinoline carboxylic acid was detected at a retention time of 17.628 min. Given the promising antimicrobial activity displayed by the crude extract of Streptomyces sp. VITGV156, further investigations are planned to gain deeper insights into its secondary metabolites.